ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Tuning functionality and bulk behaviour of micelles with cyclodextrins
Abstract: Beta-cyclodextrins (b-CD) are well tolerated in humans without toxic side effects and present in several injectable drug formulations, due to their ability to form host-guest complexes with hydrophobic species. CD host-guest interactions are also exploited in responsive supramolecular structures for applications in controlled drug delivery, medical diagnostics, nanodevices, templating, etc. We have demonstrated that various derivatives of b-CD induce very different effects in two types of micelles: either rupture (and thus release of a payload), or reinforcement. This effect can be switched-off or finely tuned by adding a competing guest (adamantane amine), which is pH sensitive. We request the use of SANS to elucidate the nanoscopic structures formed in these responsive systems and in particular the mechanism of rupture or reinforcement, and the localisation of adamantane.
Public release date: 21 May 2015
Principal Investigator: Dr Cecile Dreiss
Experimenter: Professor Margarita Valero Juan
Experimenter: Dr Marcelo da Silva
Experimenter: Dr Rubia Gouveia
Experimenter: Mr Thiago Heiji Ito
Experimenter: Dr Margarita Valero
DOI: 10.5286/ISIS.E.24088923
ISIS Experiment Number: RB1210104
Part Number: 1 - LOQ
Date of Experiment: 17 May 2012
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Cecile Dreiss et al; (2012): Tuning functionality and bulk behaviour of micelles with cyclodextrins, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.24088923
