ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
The Orientation and Conformation of an Enantiomeric Pair of 310 Helical Peptides within Supported Lipid Bilayers
Abstract: We wish to investigate the interactions between peptide mimics of peptaibols, a highly active class of natural antimicrobial peptide, and membranes. In particular we are focusing on how the membrane affects the shape of the peptides, and how the peptides alter the positioning of the lipids in the membrane. We will assess the effect of an enantiomeric pair of peptides (peptides of opposite “handedness”) on membranes (composed of lipids that themselves have a "handedness") by using neutron reflectometry (NR). The effect of lipid handedness on other molecules in the membranes is widely disregarded, but we recently found that lipid handedness does cause differences in the ways that enantiomeric peptides interact with membranes. We would therefore like to use NR to achieve detailed structural understanding of changes in membrane structure after the peptides embed in the membranes.
Public release date: 04 March 2022
Principal Investigator: Dr Simon Webb
Experimenter: Dr Maria Giovanna Lizio
Local Contact: Dr Mario Campana
DOI: 10.5286/ISIS.E.101138324
Parent DOI: 10.5286/ISIS.E.RB1910639
ISIS Experiment Number: RB1910639
Part Number: 1
Date of Experiment: 01 March 2019
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Simon Webb et al; (2019): The Orientation and Conformation of an Enantiomeric Pair of 310 Helical Peptides within Supported Lipid Bilayers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.101138324
