Published August 11, 2017 | Version v1
Dataset Open

Hypermethylation of HOOK2 gene and its relation with Type 2 diabetes susceptibility in individuals with obesity

Creators

  • 1. . Endocrinology and Nutrition Department. Hospital Universitario Central de Asturias (HUCA). Asturias. Spain
  • 2. Endocrinology and Nutrition Department. Hospital Universitario Central de Asturias (HUCA). Asturias. Spain.
  • 3. Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). HUCA. Universidad de Oviedo. Asturias. Spain.
  • 4. Surgery Department. Hospital Universitario Central de Asturias. Asturias. Spain.
  • 5. Endocrinology and Nutrition Department. Hospital Universitario Central de Asturias (HUCA). Asturias. Spain
  • 6. Centro de Investigación en Nanomateriales y Nanotecnología (CINN). El Entrego. Asturias. Spain

Description

Failure in glucose response to insulin is a common pathology associated with obesity. In this study, we analyzed the genome wide DNA methylation profile of visceral adipose tissue samples in a population of individuals with obesity and assessed whether differential methylation profiles are associated with the presence of type 2 diabetes (T2D).

More than 485,000 CpG genome sites from visceral adipose tissue samples from  women with obesity undergoing gastric bypass (n=18), and classified as suffering from type 2 diabetes or not (no type 2 diabetes, NT2D), were analyzed using DNA methylation arrays.

Notes

This work was supported by grants from the Fundación Mutua Madrileña (IX Convocatoria de Ayudas para la Investigación Clínica-2012), Instituto de Salud Carlos III (FIS PI11/02795 and FIS P14/00970) and the Sociedad Española de Diabetes (SED) (in 2012).

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