Published December 31, 2017
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DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1, 4-BENZOXAZINONE DERIVATIVES AS ANTI-MICROBIAL AGENTS
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ABSTRACT
Column chromatography is used to separate the components. Analytical and spectral data (IR, 1H NMR, and Mass) are used to identify and describe all novel compounds. Synthesized chemicals are tested for their ability to kill bacteria and fungi. The synthesised benzoxazinone derivatives were evaluated and found to be moderately to weakly antimicrobial. The antibacterial activity of the fused or combined moieties was found to be moderate to weak against Gram (+ve) and Gram (-ve) bacteria in screening experiments. Various biological activities have been attributed to the substituted benzoxazinone derivatives.
Keywords: benzoxazinone, derivatives, spectral data.
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