Data & code repository for the article "An ancestral molecular response to nanomaterial particulates"

This repository contains the relevant data and code supporting the study "An ancestral molecular response to nanomaterial particulates" (DOI: 10.1038/s41565-023-01393-4). 

In detail the following data sources have been included:

- the preprocessed transcriptomic datasets GSE157266 and GSE148705 included in the discovery set (curated_transcriptomic_data.zip);

- supplementary materials of the paper, including curated molecular descriptors panels and the ENM gene signature (supplementary_files.zip);

-The preprocessed microarray transcriptomics data for drug exposure have been curated from a selection of the Open Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System (TG-GATEs) data (transcriptomic_data_drug_exposures.zip);

-the chemical signatures collected from the Comparative Toxicogenomics Database (CTD) (CTD_signatures.zip);

-the list of dose dependent genes for individual transcriptomic dataset (dose_dependent_genes.zip);

-the relevant code and input data (code.zip and input_data.zip)