Published November 8, 2022
| Version v1
Journal article
Open
Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates
Creators
- 1. Université de Paris, IAME, INSERM F-75018 Paris, France
- 2. Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France
- 3. Institut Pasteur, Université de Paris, CNRS UMR 3528, Structural Bioinformatics Unit, Paris, France.
- 4. Inria Bordeaux Sud-Ouest, Inserm, Bordeaux Population Health Research Center, SISTM Team, UMR 1219, University of Bordeaux, Bordeaux, France. Vaccine Research Institute, Créteil, France
- 5. National Reference Center for Respiratory Viruses, Institut Pasteur, 28 rue du Docteur Roux, 75015 Paris, France.
- 6. National Reference Center for Respiratory Viruses, Institut Pasteur, 28 rue du Docteur Roux, 75015 Paris, France. Molecular Genetics of RNA Viruses Unit, Institut Pasteur, UMR3569, CNRS, Université de Paris, 28 rue du Docteur Roux, 75015 Paris, France.
Description
Contents
1. Dataset
- Full dataset of all 78 animals infected with different strains of SARS-CoV-2
2. Monolix files
- Structural models of the 5 models used
- mlxtran files of the 6 models used
3. R script files
- Main script used to reproduce all figures and results in the article
- File used to store functions used in the main script
- Result file of the simulations
Files
CompleteDataset_NasalOnly.csv
Files
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Additional details
Funding
- TheraCoV – Viral dynamics at the individual and population levels: impact for antiviral treatment optimization ANR-20-COVI-0018
- Agence Nationale de la Recherche