COMPUTATIONAL ANALYSIS OF PROGNOSIS OF MYOCARDIAL INFARCTION IN LEFT VENTRICLE
Creators
- 1. Department of Mechanical and Production Engineering, Ahsanullah University of Science and Technology, Dhaka 1208, Bangladesh
Description
Heart Failure due to Acute Myocardial Infarction (HF AMI) has emerged as a prevalent heart disease with a high risk of short-term and long-term mortality rates. HF AMI has been associated with a progressively impaired interaction between the left ventricle (LV) and the systemic arteries. Because of the lower global transverse and longitudinal strain in AMI, it's been suggested that the LV's stiffness and contractility are compromised. Reduced ejection fraction (EF) and changes in LV geometry, such as infarct zone (IZ) size and location, as well as myocardial wall qualities such as contractility and stiffness, which may also alter global strains, support these results. To resolve these challenges, we used a proven mathematical comprehensive framework of a finite element LV model to separate the effects of AMI characteristics on systolic function measures. Simulations were done to assess the impact of changes in LV shape, and myocardial stiffness on cardiomyocyte strains. We found that the simultaneous increase in myocardial stiffness may mimic the systolic blood pressures, EF, and strains reported in AMI patients. These data imply that myocardial stiffness is enhanced in individuals with HF AMI.
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References
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