RETRO - PROSPECTIVE OBSERVATIONAL COMPARATIVE STUDY ON DRUG UTILISATION OF PROTON PUMP INHIBITORS vs H2 RECEPTORS BLOCKERS

ABSTRACT

Aim of Study: The objective of the study was to assess the retrospective observational comparative study on drug utilisation of Proton Pump Inhibitors (PPI) vs H₂Receptor Blockers (H₂RB).

Methodology: 150 patients are included in the study. All the patients were undergoing proton pump inhibitors and H₂ receptor blockers therapy and /or co-morbidities were included in the study. The study was conducted in General Medicine Unit (IPD), Intensive Care Unit, Surgery, Orthopaedic and all other departments in a multi-speciality tertiary care hospital. The patient’s demographic status like name, age, gender, occupation, IP number, date of admission, etc., was collected. The appropriateness of PPIs and H₂RBs drugs like dose, dosage form, duration of treatment, route and frequency of administration with standard guidelines was also recorded.

Result: Results of patient population included in the study are 150, out of males are 98(65%) and female are 52(35%) are using Anti-Ulcer drugs. In total study population based on dose and dose frequency Pantoprazole (PPI) 40mg, OD is prescribed in 17% of prescriptions and Ranitidine (H₂RB) 150mg, BD is prescribed in 14% of prescriptions.

Conclusion: Gender, Age, Social habits, Occupation and Education status influence the occurrence of GIT problems. Based on this study, in our area, PPIs are prescribed more often than H₂RBs. In PPIs Pantoprazole (PPI) 40mg was the highest prescribed as prophylaxis to GIT damage than Ranitidine (H₂RB) 150mg.

KEYWORDS: Proton Pump Inhibitors (PPIs), H₂  Receptor Blockers (H₂RBs), NSAID Prophylaxis, Anti-Ulcer drugs.