CUCURBITACINS AND ITS ANTICANCER PROPERTY: A REVIEW

Cucurbitacins which are structurally unlike triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological activity. This diverse group of compounds may substantiate to be important lead molecules for the treatment of cancer. Research focused on this unattended medicinal compound can prove the significance and explore the hidden potential to cure various diseases. These compounds show their proposed mode of action, probable molecular targets and have future aspects of their use as a medicinal agent. This review is aimed to provide the chemical nature and medicinal property of cucurbitacins.

Keywords: Cucurbitacin, STAT, Janus kinase (JAK), anti-tumor, anti-inflammation, apoptosis.