Controlled Porosity Osmotic Pump Tablets Containing Esomeprazole Double Walled Microspheres-An Overview
Creators
- 1. Assistant Professor, Department of Pharamaceutics, Sanjo College of Pharamceutical Studies, Vellappara, Chithali, Palakkad, Kerala, India
Description
Esomeprazole is a BCS 11 compound, proton pump inhibitor used in the treatment of gastric, duodenal ulcer. The half-life of the drug is 4 hour. The drug has poor stability in acidic condition of the stomach. So, it is formulated into small sized and efficient carriers: the microspheres. To improve their residence time, bioadhesive characteristics can be coupled to develop mucoadhesive microspheres. Mucoadhesive microspheres are extensively used in targeted drug delivery due to their advantages like efficient absorption and improved bioavailability of the drugs and a much more intimate contact with the mucus layer, controlled and sustained release of drug from dosage form and exact targeting of drugs to the absorption site. Coating by enteric polymers will help to target the drug action in the intestine, particularly into the ileum region. Microsphere in conventional tablet will have disadvantages like it needs frequency of administration. Osmotic tablet will provide drug release independent of pH, but having the expense of complicated laser drilling. The main advantages of controlled porosity osmotic pump (CPOP) are reduced stomach irritation, no complicated laser-drilling procedures are followed.
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(6-10)Controlled Porosity Osmotic Pump (Cpop) Tablets Containing Esomeprazole-format.pdf
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Additional details
References
- Muruganantham V, Jaykar B (2016), "Design & evaluation of buccal tablets of drug loaded microspheres", JCPS, Volume 9, Issue 2, pp. 673−678.
- Naresh Vishal Gupta, Shirodker Natasha et al. (2013), "Bioadhesive Vaginal Tablets Containing Spray dried microspheres loaded with Clotrimazole for treatment of Vaginal Candidiasis", Acta Pharm., Volume 63, pp.
- Supriya Shidhaye, Sheetal Malke et al. (2008), "Taste Masked Orally Disintegrating Tablet Containing Microsphere for Immediate Release", Journal of Pharmacy Research., Volume 1, Issue 2,
- Gamal A Shazly (2013), "Formulation and evaluation of fast dissolving tablets containing taste-masked microspheres of diclofenac sodium for sustained release", Digest Journal of Nanomaterials and Biostructures., Volume 8, Issue 3, pp. 1281–1293.
- Shivangi Singh (2016), "Formulation and evaluation of metronidazole tableted microspheres for colon drug delivery", Asian J Pharm Clin Res., Volume 9, Issue 3, pp. 398−403.
- Tiwari S, Verma P (2008), "Microencapsulation technique by solvent evaporation method (Study of effect of process variables)", Int J Pharm Life Sci., Volume 8, Issue 2, pp. 998−1005.
- Redasani V, Jaiswal SB et al. (2012), "Tabletting and coating multiparticulates", Int J Phar Res Dev., Volume 3, Issue 11, pp. 153−159.
- Das MK, Senapati PC (2007), "Evaluation of furosemide loaded alginate microspheres prepared by ionotropic external gelation technique", Acta Poloniae Pharm Drug Res., Volume 64, Issue 3, pp. 253−262.
- Priya Shahi et al. (2015), "Microspheres and tablet in capsule system: A novel chronotherapeutic system of ketorolac tromethamine for site and time specific delivery", International Journal of Pharmaceutical Investigation., Volume 5, Issue 3, pp. 161−170.
- Shah N, Patel M et al. (2011), "Design, development and optimization of colon targeted drug delivery system for Crohn'sdisease", Indian J Pharm Educ Res., Volume 2, pp. 42−50.