EVALUATION, HEPATOPROTECTIVE EFFECTS AND THE DETERMINATION OF SAFTY AND EFFICACY OF ZOSIMA ABSINTHIFOLIA

Zosima absinthifolia (family Apiaceae) is a traditional medicinal plant of Balochistan, Pakistan, Used to reduce bowel disorders, to treat cough, stomach gas and indigestion. Present study was performed to determine the Hepatoprotective activity of Z. absinthifolia. For chronic toxicity the test animals were rabbits were administered Z. absinthifolia 300mg/kg/ given orally for 3 months The biochemical parameters (blood glucose, Kidney function test, hematological parameters, cardiac enzymes, liver function test, urea, lipid profile, and serum calcium) were determined. Current study reveals that the Z. absinthifolia methanol extract showed non significant changes in cardiac enzymes (LDH), lipid profile (Triglycerides and Cholesterol level) and hematological profile while significant increase platelets count was observed. Result of present study shows that Z. absinthifolia's methanol extract posses Hepatoprotective effect with non toxic profile.