Larvicidal Activity of Celosin A, A Novel Compound Isolated from Celosia Argentea Linn

Mosquitoes are the most dangerous diseases spreading vector and one of the important vector is Aedesaegypti. Natural products act as toxic agents and its active principles as an alternative mosquito control strategy was available from ancient times. These are nontoxic, easily available at affordable prices, biodegradable and show broad-spectrum target-specific activities against different species of vector mosquitoes. Pharmacological and Phytochemistry uses of Celosia  argentea Linn shown health benefits of including anti- oxidant, anti-diarrhoeal, Anti-diabetic, nutritive, bile  juice increase and use as blood Tonic. The phytochemical evaluation of whole plant of Celosia argentea was examined but larvicidal (Aedesaegypti) activity remains unknown. In this article, we explored the larvicidal activity of Celosia argentea(leaf and root extracts), its active principle Celosin A (isolated from leaf and root). Lethal concentration (LC50) was against fourth instar larvae of Aedesaegypti by leaf (LC 10.66ppm) and root (LC50 1.8ppm). Interestingly, Celosin A is the major (45%) compound isolated from leaf and root extracts, which shown the LC50 1.488ppm. For the first time, we studied the Celosin A chemical nature against mosquito and it can be a future drug or toxicant against Aedesaegyptilarva.