Published January 9, 2024
| Version v1
Dataset
Open
Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity
Creators
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Moorlag, Simone J.C.F.M.1
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Folkman, Lukas2, 3
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ter Horst, Rob2
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Krausgruber, Thomas2, 3
- Barreca, Daniele2
- Schuster, Linda C.2
- Fife, Victoria2
- Matzaraki, Vasiliki1
- Li, Wenchao4, 5
- Reichl, Stephan2, 3
- Mourits, Vera P.1
- Koeken, Valerie A.C.M.1
- de Bree, Charlotte L.J.1, 6, 7
- Dijkstra, Helga1
- Lemmers, Heidi1
- van Cranenbroek, Bram
- van Rijssen, Esther8
- Koenen, Hans J.P.M.8
- Joosten, Irma8
- Xu, Cheng-Jian1, 4, 5
- Li, Yang1, 4, 5
- Joosten, Leo A.B.1
- van Crevel, Reinout1
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Netea, Mihai G.1, 9
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Bock, Christoph2, 3
- 1. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands
- 2. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
- 3. Medical University of Vienna, Institute of Artificial Intelligence, Center for Medical Data Science, Vienna, Austria
- 4. Department of Computational Biology of Individualised Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Hannover Medical School (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany
- 5. TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany
- 6. Bandim Health Project, OPEN, Institute of Clinical Research, University of Southern Denmark/Odense University Hospital, Odense, Denmark
- 7. Danish Institute for Advanced Study, University of Southern Denmark, Odense, Denmark
- 8. Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, Netherlands
- 9. Department for Immunology and Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany
Description
This repository contains personal immune profiles of 323 healthy individuals (300BCG) subjected to Bacillus Calmette-Guérin (BCG) with blood samples collected immediately before (day 0), and 14 and 90 days after the vaccination. The personal immune profiles comprise:
- immune cell concentrations measured with flow cytometry and a hematology analyzer
- plasma concentrations of 73 circulating inflammatory markers
- 30 measurements of cytokine and lactate production capacity of peripheral blood mononuclear cells (PBMCs) in response to four microbial stimuli (Candida albicans, Escherichia coli lipopolysaccharide [LPS], Staphylococcus aureus, Mycobacterium tuberculosis).
Visit http://300BCG.bocklab.org/ to learn more.
Files
!README.md
Files
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