Polymorphism of IL-10 gene (rs1800896), in obese and smokers of Covid-19 patients in Wasit Province, Iraq

An inflammatory response and an interleukin 10 (IL-10) cytokine storm were associated with serious acute lung injury and multiorgan dysfunction in patients with severe COVID-19 disease. Genetic variations affecting IL-10 levels and disease are known as single nucleotide polymorphisms (SNPs). Severe COVID-19 was more likely in older adults, those who were overweight, and smokers.  Purpose: To determine if COVID-19 is associated with IL-10 gene SNPs at (rs1800896) in individuals who smoke and are overweight. The participants in this study were 24 people with COVID-19 who were overweight, 25 people who smoked, 25 people who were neither overweight nor smokers (control positive), and 21 healthy individuals. The groups that were studied underwent ARMS-PCR genotyping of the IL-10 (rs1800896) SNP. Three samples had the A allele (3.2%), eight samples had the G allele (8.4%), and eighty-four samples had the AG genotype (88.4%). Within the same groups, there was a substantially different prevalence rate of IL-10 (rs1800896) alleles, with low rates of AA and GG genotypes (P< 0.0001).