Comprehensive Assessment of the Impact of MSG and Soybean Consumption on Metabolic Health and Antioxidant Enzyme Activity

OBJECTIVES

This study aimed to investigate the enduring physiological impacts of prolonged monosodium glutamate (MSG) and soybean consumption in rats, with a specific focus on liver and kidney function, antioxidant enzyme activities, and oxidative stress markers. Gender-specific differences in responses were also explored.

METHOD

Female and male rats were subjected to varying doses of MSG and soybeans over a 6-month period. Physiological responses were meticulously analyzed, encompassing liver enzyme concentrations, urea and creatinine levels, as well as antioxidant enzyme activities (superoxide dismutase, catalase, and glutathione peroxidase). Statistical methods were employed to assess the significance of observed alterations.

RESULT

Significant perturbations in liver enzyme concentrations were noted, indicative of potential hepatotoxic effects linked to MSG and soybean intake. Changes in urea and creatinine levels suggested potential renal implications, particularly for individuals with kidney-related conditions. Disturbances in antioxidant enzyme activities reflected compromised defense mechanisms against oxidative stress, with heightened malondialdehyde levels indicating increased lipid peroxidation. Gender-specific differences in responses were observed.

CONCLUSION

This study underscores the necessity for personalized dietary recommendations, considering individual variations in responses to MSG and soybeans. Caution is warranted for individuals with pre-existing health conditions, particularly those related to liver and kidney function. The findings emphasize the importance of public awareness regarding the risks associated with excessive MSG and soybean consumption. Healthcare providers should integrate these considerations into dietary advice, especially for patients with existing health conditions. Further research is advocated to comprehensively understand the long-term consequences on human health, and regulatory bodies should incorporate these findings into guidelines for ensuring public safety amidst widespread MSG and soybean consumption.