PREPARATION AND EVALUATION OF CONTROLLED RELEASE TABLETS CONTAINING IBUPROFEN

The present study aimed at Formulation Development and Evaluation of controlled release tablets of Ibuprofen is nonsteroidal anti-inflammatory drug (NSAID) class that is used for treating pain, fever, and inflammation. This includes painful menstrual periods, migraines, and rheumatoid arthritis. It may also be used to close a patent ductus arteriosus in a premature baby. It can be used by mouth or intravenously.

The matrix tablets of Ibuprofen were prepared using direct compression method. Physical characterization of tablet and powder blends used to form the matrix tablet was under taken using a range of experimental techniques. Granules were evaluated for Bulk density, Tapped density, Compressibility index and Hausner's ratio. Tablets were tested for weight variation, hardness, thickness and friability as per official procedure. The tablets were evaluated for in-vitro drug release profile. Dissolution studies of Ibuprofen controlled release tablets in media with different dissolution media 0.1N HCl, Phosphate buffer pH (6.8) as per US Pharmacopoeia.

The drug release from optimized formulations was controlled for a period of 12 hrs. The kinetic treatment of selected formulation (F3) showed that the release of drug follows Peppas release kinetics mechanism. Results of the present study indicated the suitability of different polymers in the preparation of matrix based controlled release formulation of Ibuprofen. Several kinetic models were applied to the dissolution profiles to determine the drug release kinetics.

Keywords: Ibuprofen, HPMC K 15M, HEC 2M, HPC 2M and Controlled release tablets.