National Journal of Research in Ayurved Science Preparation and Standardization of Jatyadi Ghrita Rectal Suppository

- Jatyadi Ghrita is a very well known formulation used for wound healing, anorectal disorders like fissure, fistula or any chronic wound . These wound healing properties of Jatyadi ghrita can be used in modern dosage form like suppository, suppositories are used to improve local effect of Jatyadi ghrita because of its easy application and minimum local discomfort. These suppositories are made by fusion or melt method by using cocoa butter as a base, and melted mixture of both are poured into molds and after cooling suppositories are collected from molds and stored in fridge. Temperatures plays major role in preparation of this fusion or melt method suppositories. An attempt has been made for preparation and standardization of Jatyadi ghrita suppositories. Standard Preparation method and Visual examination, melting point, liquefaction time of suppositories are studied under this project.


Introduction -
Jatyadi Ghrita is a classical Ayurvedic formulation prepared from Jati (Jasminum officinale), Nimb ( In modern science Suppositories are solid dosage forms of various weights and shapes, usually medicated, for insertion into rectum, vagina or urethra. Pharmaceutical formulations meant for insertion into body cavities other than the mouth. Drugs having systemic effects such as sedatives, tranquilizers and analgesics are administered by rectal suppositories; however the largest single use category is probably that of hemorrhoid remedies dispensed over the counter. 7 The goal of the study is to prepare rectal suppository from Jatyadi Ghrita because Jatyadi Ghrita is indicated in the treatment of various types of ulcers. It has proven wound healing properties. 8 This property of Ghrita can be used in Anal disorders like fissure, Hemorrhoids by making its rectal suppository, hence an attempt was made to develop standardized new formulation from Jatyadi Ghrita to improve the local effect in wound healing in suppository form. Aims -To prepare and standardize rectal suppository from Jatyadi Ghrita. Objectives -1. Preparation of Jatyadi Ghrita.

Materials and Methods 1) Preparation of Jatyadi Ghrita -500Gm
Goghrita were taken in steel vessel and kept for heating on mild fire, After it gets heated prepared kalka of fresh Nimbapatra, fresh jatipatra, churna of Patol, Kutaki, daruharidra, Haridra, Sariva, Manjishtha, Haritaki, Yashtimadhu, Karanja Beeja and shuddha Tuttha, Siktha each of quantity 9 gm were added to this heated ghrita and then 2 litres of water is added, heat was given at 50 0 C till siddhi lakshanas are obtained. Prepared Jatyadi ghrita is then filtered through muslin cloth and allow to cool 9 .

2) Preparation of Jatyadi Ghrita
Suppository -Suppositories are made by fusion or melt method. In this method the Jatyadi ghrita is dissolved in melted suppository base, the mixture is then poured into a suppository mold, allowed to cool and

Visual Examination -
Color -by using color chart actual color of the product is determined.
Shape -Shape of the suppository is continuous or not is determined.
Surface Condition -Product was observed to determine the smoothness, cracks, dark regions, bursts, air bubbles, holes etc.
Appearance -Dry, oily or moist appearance of the suppository is determined.
Feel -by touching the product stickiness hardness of the suppository is determined. Odor

Discussion -
In present study standardized rectal suppository was formulated to replace the traditional ghrita dosage form. All Analytical study for raw drug standardization was carried out and it matches the standard values given in Ayurvedic Pharmacopoeia of India.
Prepared Jatyadi ghrita has green color because of fresh Jati and Nimba Leaves, and density of 0.91023 wt/ml, this density was helpful to determine the weight of cocoa butter in the suppository.
Cocoa butter is a frequently used base for suppositories which is easily available and this type of suppository is feasible to prepare. This fusion or melt method suppositories are formulated on a weight basis, in this medication Jatyadi ghrita is replaces a portion of the vehicle cocoa butter as a function of specific gravity. In this formulation, for preparation of 2 gm suppository 0.5493 gm of Jatyadi Ghrita and 1.4507 gm of Cocoa butter was used. The temperature plays main role in the preparation of such type of fusion or melt method suppositories especially with base cocoa butter that is theobroma oil, because cocoa butter is naturally occurring triglyceride about 40 % of fatty acid is unsaturated, it melts quickly at body temperature. Hence, in the preparation of suppositories if cocoa butter overheated, molded and chilled the suppositories will melt below 30 0 C, therefore it is prepared in temperature of 40 0 C to 50 0 C to avoid change in crystal form and melting point.

Conclusion -
Jatyadi Ghrita is locally used medicine for anorectal diseases as well as it has proven wound healing properties. This property can be used in rectal suppository form hence and attempt has been made to prepare the jatyadi ghrita suppository, It has standard parameters like Green color, Hard, Bullet shaped, Smooth and oily surface, without any odor, with 2 gm weight, Melting point 36.3 0 C, liquefaction time of 7.32 minutes. It is necessary to do further study on this topic to have more corrective and different methods of preparation of suppository with different bases, also it gives the standard method and parameters for Jatyadi ghrita suppository.