Effect of Raphanus Sativus (Radish) Leaf Extract on Atorvastatin Induced Hepatotoxicity in Rabbits

Abstract

Objectives: To investigate hepato-protective effect of ethanolic leave extract of Raphanus sativus against atorvastatin
induced hepatotoxicity in albino rabbits.
Study design: Experimental study
Material and Method: This study conducted at department of Physiology and Pharmacology, University of Agriculture,
Faisalabad. The ethanolic extract of Raphanus sativus was prepared for hepatoprotective effect against hepatotoxicity
produced by atorvastatin.
Results: The results were compared with normal and experimental control. Serum was tested for ALT, AST, Alkaline
Phosphatase and Bilirubin along with histological studies. Ethanolic extract of Raphanus sativus with 100mg/kg. of body
weight dosage developed some changes representing hepatotoxicity but higher doses showed an increase in toxicity as
observed on histologic sections. A reduction in fibrosis and cholestasis was observed which needs further evaluation.
Conclusion: Ethanolic extract of raphanus sativus did not show any amelioration in the increased enzymes level however
a reduction in cholestasis was observed as represented by decreases in alkaline phosphatase levels also confirmed by
histological studies.