Magmatic activities in sedimentary basins provides abnormal heat sources and exert significant impact on the regional temperature field. In previous studies, the anomalous thermal effects of magmatic activities of multiple scales were studied. Small-scale intrusions (cm-m) can conduct high-temperature thermal baking of surrounding strata within tens to hundreds of meters. Basin-scale heat flow anomalies caused by mantle plume upwelling have also received increasing attention. In contrast, the thermal effects of large igneous plutons (several km to tens of km) have received little attention. A few studies have shown that the large intrusive bodies can affect the temperature field within a range of tens of kilometers. The Permian large igneous province is widely distributed in the Tarim Basin, forming several large plutons. The Manalik pluton is a large intrusive body in the northwestern Tarim, with a long diameter of up to 40 km. We have measured the clumped isotope of different calcite fabrics from the Ordovician carbonate intervals surrounding the contact aureoles of Manalik pluton. In-situ U-Pb dating will be applied to these fabrics to provide starting anchors for thermal history modeling using solid-state reordering models of carbonate clumped isotope. In addition, Silurian sandstones from the same area were collected for zircon (U-Th)/He age measurement and subsequent thermochronological thermal history inversion. Compared with conventional thermal indicators applied in deeply buried strata (e.g., vitrinite reflectance), the integration of the two thermochronological tools (Δ47/U-Pb and zircon U-TH/He) holds the advantage in more accurately quantifying the abnormal thermal effects of kilometer-scale intrusive bodies. The experimental results show that zircon (U-Th)/He and clumped isotope jointly constrain temperatures exceeding 200°C in Well Shengli 1 and Well Yingmai 35, which are closest to the Manalik pluton; the thermal anomalies identified in Well Yudong 2 are as high as 220°C; Well Yingmai 2 Well and Yingmai 34, which are far away from the igneous intrusion, were not affected by the thermal contact aureoles of Manalik pluton during the Permian period, and the current burial temperature is the highest paleogeothermal temperature experienced in historical periods. Based on the zircon (U-Th)/He and U-Pb/Δ47 simulation results, we reveal that the Manalik pluton has a significant thermal baking effect on the area within 20km, and the maximum temperature in the area close to the igneous pluton can exceed 220°C. The results of this study provide typical cases and inspiration for identifying and quantifying the thermal effects of contact aureoles in other basins where large igneous pluton are developed.