We focuses physiological activities of oyster extract and its possible indication to liver functional impairment, and investigated the effect of oyster extract on hepatic function in 20 male and female candidates with mild alcoholic liver damage by 12 weeks ingestion of oyster extract (Japan Clinic Co., Ltd.) prepared from Crassostrea gigas. Throughout the study period, there was no ethical issues and intentional or accidental medical accident.

The subjects with mild alcoholic liver damage ingested 4 pills (containing 230 mg of Oyster Extract Powder in 1 pill), tid, for 12 weeks. Physical examination, urinalysis, hematology, blood chemistry and clinical examinations by doctor were conducted at 0, 4, 8 and 12 weeks.

As the results, significant reduction was observed for ALT and ALP in male and female subjects and for γ-GTP in male subject at 12 weeks. A tendency of reduction to the reference ranges was observed for AST at 12 weeks.

As shown above, it was suggested that the hepatic functions of the subjects with mild alcoholic liver damage will be improved by 12 weeks ingestion of oyster extract.