Clinical Study on Nicotinamide Phosphoribosyl Transferase and SIRT1 Level in Patients With Neutropenia After Chemotherapy for Lung Cancer

Yukari TSUBATA; Tomomi AKITA; Ryosuke TANINO; Takamasa HOTTA; Ayano TEZUKA; Misato KOBAYASHI; Takae OKUNO; Yohei SHIRATSUKI; Akari TANINO; Megumi HAMAGUCHI; Chikamasa YAMASHITA; Takeshi ISOBE

doi:10.51010/sjms.38.4_119

Original Article

Clinical Study on Nicotinamide Phosphoribosyl Transferase and SIRT1 Level in Patients With Neutropenia After Chemotherapy for Lung Cancer

Yukari TSUBATA , Tomomi AKITA, Ryosuke TANINO, Takamasa HOTTA, Ayano TEZUKA, Misato KOBAYASHI, Takae OKUNO, Yohei SHIRATSUKI, Akari TANINO, Megumi HAMAGUCHI, Chikamasa YAMASHITA, Takeshi ISOBE

Author information

Yukari TSUBATA [Japan] Corresponding author
Division of Medical Oncology & Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan
Tomomi AKITA
Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan
Ryosuke TANINO
Division of Medical Oncology & Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan
Takamasa HOTTA
Division of Medical Oncology & Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan
Ayano TEZUKA
Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan
Misato KOBAYASHI
Division of Medical Oncology & Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan
Takae OKUNO
Division of Medical Oncology & Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan
Yohei SHIRATSUKI
Division of Medical Oncology & Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan
Akari TANINO
Division of Medical Oncology & Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan
Megumi HAMAGUCHI
Division of Medical Oncology & Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan
Chikamasa YAMASHITA
Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan
Takeshi ISOBE
Division of Medical Oncology & Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan

Keywords: chemotherapy, lung cancer, neutropenia, SIRT1 expression

JOURNAL FREE ACCESS FULL-TEXT HTML

2021 Volume 38 Issue 4 Pages 119-125

DOI https://doi.org/10.51010/sjms.38.4_119

J-STAGE : sjms 39 1 pp.47-

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Abstract

The NAD⁺–sirtuin 1 (SIRT1) pathway is essential for neutrophil differentiation induced by the granulocyte-colony stimulating factor, and thus may contribute to neutropenia observed after cancer chemotherapies. This study aimed to investigate the relationship between neutropenia and indices for the activity of the NAD-SIRT1 pathway, i.e., nicotinamide phosphoribosyltransferase (NAMPT) activity and SIRT1 expression in patients receiving chemotherapy for lung cancer. Blood samples were collected from sixteen patients at the start of chemotherapy, at the nadir, and before the start of the second chemotherapy course. Neutrophil counts, NAMPT activity and SIRT1 expression level were measured. There were no differences observed either in NAMPT activity or in SIRT1 expression level between the cases of grade 3–4 neutropenia and those of grade 0–2 neutropenia though the SIRT1 expression level tended to decrease at the nadir. Further studies are required to elucidate this relationship between post-chemotherapy neutropenia and SIRT1 expression.

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