2014 年 72 巻 10 号 p. 1154-1155
Functionalizations of carbonyl compounds are absolutely essential transformations in the field of organic synthesis. Carbonyl functional moieties readily react with nucleophiles (at ipso-carbon) and electrophiles (α-carbon substitution), however, the direct β-functionalization of α,β-saturated carbonyl compounds is rare, and poses a synthetic challenge. Two novel β-activation methodologies appeared in 2013, enabled by organocatalysts.