In this report we describe the clinical and histological findings of osteopetrosis. She was 29 year-old and admitted to our hospital for treatment of the fracture of right femur.
She had typical histories such as recurrent fractures of left femur, osteomyelitis of right mandibula, hardness of hearing, dumbness, nystagmus and optic atrophy. Biochemical investigation revealed high serum alkaline and acid phosphatase. The X-ray pictures demonstrated typical osteopetrosis just like as chalk bone in skull, rib, spine, pelvis and femur bones. Histologically the bone taken from the iliac crest showed irregular osteoid and chondral matrix, and callus taken from the fractured femur bone showed focal bone formation but no lamellar bone trabeculae. We treated the fracture by internal fixation using a plate but there was no sign of bone union.