The reasonability of water emergency facilities location in the Yangtze River has great influence on the water emergency rescue capabilities. Based on the different levels of the the rescue object of water emergency facilities, the characteristics of water emergency facilities location in the Yangtze River is analyzed. Then, the multiple-coverage location model of water emergency facilities location in the Yangtze River is constructed, and the ant colony algorithm is applied to solve the model. Finally, the model is verified by the example of water emergency facilities in the Three Gorges Reservoir area, which is presented to find out the location plan.