Onchocerciasis Transmission in Africa and How It Can Be Resolved

Obstacles and Solutions to the Spread of Onchocerciasis Transmission in Africa

Authors

  • Saketh Nallagatla Gifted Gabber
  • Dr. Raj Gifted Gabber
  • Jo Gifted Gabber

DOI:

https://doi.org/10.47611/jsrhs.v11i3.2664

Keywords:

Onchocerciasis, Wolbachia Bacteria, Doxycycline, Ivermectin, Ioiasis

Abstract

Onchocerciasis is a parasitic infection that affects the skin and eyes and is transmitted by black flies which predominantly affect rural areas. Onchocerciasis symptoms are caused by microfilariae that travel through the skin and eyes to cause lesions, dermatitis, and blindness. These microfilariae are key in diagnosing Ivermectin by their presence in the skin and eyes which can be determined with skin snips or exposure to certain chemicals. Onchocerciasis in Africa is spread along river areas and efforts to wipe it out have failed because transmission zones have not been fully mapped out, Onchocerciasis is coendemic with Loiasis in certain areas, Onchocerciasis-causing parasites are developing Ivermectin resistance, there is a lack of coordination among countries with shared transmission zones, violent conflict diverts focus from the elimination of Onchocerciasis transmission, and these countries lack the funding to perform large-scale, accurate diagnosis procedures and deliver treatments on a more individual basis.

Downloads

Download data is not yet available.

References or Bibliography

Boussinesq, M., Fobi, G., & Kuesel, A. C. (2018, March 1). Alternative treatment strategies to accelerate the elimination of Onchocerciasis. International health. Retrieved January 16, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881258/

Centers for Disease Control and Prevention (CDC). (2013, May 24). Progress toward elimination of onchocerciasis in the Americas - 1993-2012. MMWR. Morbidity and mortality weekly report. Retrieved January 16, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604938/

Gebrezgabiher, G., Mekonnen, Z., Yewhalaw, D., & Hailu, A. (2019, July 4). Reaching the last mile: Main challenges relating to and recommendations to accelerate onchocerciasis elimination in Africa. Infectious diseases of poverty. Retrieved January 16, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609392/

Mackenzie, C., Kollmann, M., Specht, S., & Sodhalon, Y. (2018). River blindness: Reducing the prevalence of clinical disease. Community eye health. Retrieved January 16, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998396/

Rodríguez-Pérez, M. A., Fernández-Santos, N. A., Orozco-Algarra, M. E., Rodríguez-Atanacio, J. A., Domínguez-Vázquez, A., Rodríguez-Morales, K. B., Real-Najarro, O., Prado-Velasco, F. G., Cupp, E. W., Richards, F. O., Hassan, H. K., González-Roldán, J. F., Kuri-Morales, P. A., & Unnasch, T. R. (2015, July 10). Elimination of onchocerciasis from Mexico. PLoS neglected tropical diseases. Retrieved January 16, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498594/

Tekle, A. H., Zouré, H. G. M., Noma, M., Boussinesq, M., Coffeng, L. E., Stolk, W. A., & Remme, J. H. F. (2016, June 27). Progress towards onchocerciasis elimination in the participating countries of the African programme for Onchocerciasis Control: Epidemiological Evaluation Results. Infectious diseases of poverty. Retrieved January 16, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924267/

Winthrop, K. L., Furtado, J. M., Silva, J. C., Resnikoff, S., & Lansingh, V. C. (2011, April). River blindness: An old disease on the brink of elimination and control. Journal of global infectious diseases. Retrieved January 16, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125028/

Darvin Scott Smith, M. D. (2021, July 19). Onchocerciasis (river blindness) workup: Laboratory Studies, Imaging Studies, other tests. Onchocerciasis (River Blindness) Workup: Laboratory Studies, Imaging Studies, Other Tests. Retrieved January 22, 2022, from https://emedicine.medscape.com/article/224309-workup#:~:text=Traditionally%2C%20a%20diagnosis%20of%20onchocerciasis,in%20early%20stages%20of%20infection.

Taylor, H. R., Munoz, B., Keyvan-Larijani, E., & Greene, B. M. (1989, October 1). Reliability of detection of microfilariae in skin snips in the diagnosis of onchocerciasis. AJTMH. Retrieved January 22, 2022, from https://www.ajtmh.org/view/journals/tpmd/41/4/article-p467.xml

Udall, D. N. (2007, January 1). Recent updates on Onchocerciasis: Diagnosis and treatment. OUP Academic. Retrieved January 22, 2022, from https://academic.oup.com/cid/article/44/1/53/433399?login=true

Published

08-31-2022

How to Cite

Nallagatla, S., Appavu, D. R., & Kethar, J. (2022). Onchocerciasis Transmission in Africa and How It Can Be Resolved: Obstacles and Solutions to the Spread of Onchocerciasis Transmission in Africa. Journal of Student Research, 11(3). https://doi.org/10.47611/jsrhs.v11i3.2664

Issue

Section

HS Research Projects