ABSTRACT
Reports of regional grey matter volume (GMV) anomalies in patients with gambling disorder (PGD) are inconsistent, which can be attributed to methodological disparity and inattention to individual variability. Voxel-based morphometry was used to compare GMV between 25 PGD and 25 healthy controls. Additionally, the study explored associations of interpretative bias (IB, the tendency to reinterpret gambling outcomes) and negative urgency (NU, the tendency to act rashly under negative affect) with GMV in patients. These measures were chosen based on their sound association with gambling disorder in related studies. GMV tests were corrected across the whole brain (using a combination of voxel and cluster-level thresholds for a clusterwise-equivalent p ≤ 0.05). GMV was smaller in PGD than in controls in the dorsomedial prefrontal cortex. In PGD, a stronger cognitive distortion (higher IB) was associated with reduced GMV in the dorsal anterior cingulate; and patients with higher levels of impulsivity (higher NU) presented reduced GMV in the right ventrolateral prefrontal cortex. These findings are consistent with recent studies exploring individual differences in GD. However, the area discriminating between groups showed no overlap with the ones associated with IB and NU. These traits are thus unlikely to be responsible for between-group GMV differences.
