13th World Congress for Laser Dentistry
26-28, April 2012
Barcelona, Spain
Meeting Abstract
Sponsors: World Federation for Laser Dentistry
- Poster 89
TITLE: Effect of Laser Phototherapy on
Chemotherapy-Induced Hypofunction of Salivary Glands:
Histological Study.
AUTHORS: Simões A, de Campos L,
Arana-Chavez VE.
Oral Biology Laboratory, Department of Dental Materials, School of
Dentistry, University of Sao Paulo
SOURCE: Med
Oral Patol Oral Cir Bucal.
2012 May 1;17(Supplement1):S237.
* doi:10.4317/medoral.17643737
http://dx.doi.org/10.4317/medoral.17643737
Abstract
Oral hyposalivation
and xerostomia are debilitating side effects of antineoplasic treatments. Although several reports have
shown the beneficial effects of laser phototherapy (LPT) on the treatment of
these complications, little information is still available in relation to its
effects upon salivary gland (SG) tissue. The present study aimed to investigate
the histological characteristics of parotid and submandibular SG from Syrian
(golden) hamsters treated with 5-Fluorouracil (5-FU) followed or not by LPT.
Thirty five animals were divided into three groups: G1, negative control
(normal); G2, positive control (treated with 5-FU); and G3 (treated with 5-FU +
LPT, λ780 nm, 5 J/cm2 on SG areas). The experiment time was for 10
consecutive days. The 5-FU was administered at the three first days and LPT was
performed between the fourth and tenth days. SG were removed, fixed, processed
for embedding in JB4 historesin and examined under
light microscopy. Results showed the G2 specimens with their end secretory
pieces small with no discernible boundary between their cells, particularly in
the submandibular gland, while the stroma appeared
increased; in parotid glands, a acinar
atrophy was clearly observed. The G3 exhibited a recovery of tissue alterations
in parotid glands, while no apparent changes on submandibular glands after LPT
could be detected.
The results of this study suggest that LPT could preserve the structure of parotid glands affected by chemotherapy.