13th World Congress for Laser Dentistry

26-28, April 2012

Barcelona, Spain

Meeting Abstract

Sponsors: World Federation for Laser Dentistry

- Oral Presentation 54

TITLE: Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells with laser.

AUTHORS: Fekrazad R, Sheikholeslami F, Hakimiha N, Farokhi E, Kalhori K.

AJA University of Medical Sciences, Laser Reserch Center of Dentistry; Tehran University of Medical Sciences

SOURCE: Med Oral Patol Oral Cir Bucal. 2012 May 1;17(Supplement1):S54.

* doi:10.4317/medoral.17643553

http://dx.doi.org/10.4317/medoral.17643553

Abstract

Introduction: Worldwide, oral squamous cell carcinoma (potentially mediated by HER2) is recognized as the most commonly occurring malignant neoplasm of the oral cavity. Anti-HER2 nanobodies conjugated to gold-silica nanoshells and used as photothermal treatment for oral squamous cell carcinoma may provide a novel therapeutic alternative to current treatment for this disease.

Material and methods: KB epithelial or HeLaS3 cell cultures (controls) were exposed to these immunonanoshells, and plasmon resonance electron initiation specific to gold was employed to burn the tumor cells.

Results: Following this treatment, significant cell death occurred in the KB tumor cell cultures while there was no evidence of cellular damage or death in the HeLaS3 cell cultures.

Conclusion: These findings suggest that photothermal treatment of oral squamous cell carcinoma has consi-derable advantages.