The coronavirus disease 2019 (COVID-19) pandemic is one of the biggest challenges humanity has ever encountered with unfathomable aftermaths on all aspects of our lives including the health care system or rather the disruption of health care delivery.

Interestingly, diabetes and COVID-19 are both pandemics with distinct opposite features. The COVID-19 pandemic is a newly emerged infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In the short period of time, it caused over 1850941 deaths[1] rising as a global emergency and changing the face of health care provision in a short period of time. On the other hand, diabetes is a slow pandemic, and one of the leading causes of mortality and morbidity worldwide responsible for over 42 million deaths in 2019[2].

Moreover, clinical presentation of SARS-CoV-2 infection tends to be more severe with increased mortality rates in people with type 1 and type 2 diabetes, especially those with poor glycemic regulation and accompanying comorbidities such as obesity, kidney impairment, and cardiovascular disease[3,4]. An increase in mortality rates in diabetic patients, both type 1 and type 2, has been observed in the first 3 mo of 2020 compared with the same period in the 5 years prior (from 2014 to 2019), which could be a consequence of inadequate health care as well as COVID-19[3] emphasizing an urgent need for practical solutions in remote outpatient health care.

If anything, the COVID-19 pandemic accelerated the implementation of telemedicine worldwide due to mandatory social distancing, and many patients’ health care providers were discovering benefits attached to remote health care[5]. Patients can receive guidance and consulting from their homes thus avoiding a potential virus threat, saving time and costs of travel and parking, which is especially convenient for children and the working population.

This form of diabetes management is particularly appropriate for type 1 patients already using available software, such as Dexcom, Care Link, or LabVIEW, able to generate ambulatory glucose profile reports, and using smart insulin pens thus allowing remote monitoring of glucose management and providing consultations based on available data via phone, video calls, or smart phone applications[6-8].

Indeed, the digital revolution commenced in the type 1 community starting with insulin pumps, advancing with sensors, integrated and closed loop systems, ambulatory glucose profile software, and smart phone apps procuring necessary essentials for swift and timely telemedicine implementation right at the beginning of the COVID-19 pandemic[9].

This was clearly shown in a study performed in Italy during the COVID-19 lockdown including people with type 1 diabetes using the hybrid closed loop demonstrating improved glycemic control probably due to the availability of telemedicine and more active engagement of patients in glycemic management[10].

A study conducted on type 1 diabetes patients from 89 countries encompassing 7477 survey responses showed that 30% believed their healthcare access was negatively affected, while 28% received remote care through telephone (72%) or video calls (28%). The majority of those patients considered teleconsulting useful, and hemoglobin A1c levels positively correlated with affirmative attitude towards telemedicine[11].

In the pre-COVID-19 era, virtual consultations have proven useful, effective, and accessible in type 2 diabetes management compared to face-to-face visits[12,13]. Still, outcomes in terms of glycated hemoglobin vary by studies. For instance, Cochrane meta-analysis of 21 studies comparing standard care to telemedicine in diabetic patients demonstrated inconsistent results in hemoglobin A1c improvement but a better effect on low density lipoprotein and blood pressure levels[14]. Another study showed improvement in hemoglobin A1c levels. However, strong technical support was engaged including connected devices such as continuous glucose monitoring, remote lifestyle coaching, and clinical support with a mobile app, which are not usually on disposal for type 2 diabetes patients[15].

Data on telemedicine and type 2 diabetes in the COVID-19 era are still lacking. In a recently published study including 763 type 1 and 619 type 2 diabetics, about 40% of patients stated that all of their diabetes visits were cancelled or postponed, 40% were switched to telehealth consultations, while half reported lower overall satisfaction with these visits[16].

Infection with SARS-CoV-2 causes an inexplicable rise in glycemia, probably due to direct toxic effects of the virus itself and wide expression of angiotensin converting enzyme 2 on islet cells[17,18] presenting with acute hyperglycemia followed by ketosis or even ketoacidosis requiring an emergency room visit even in previously well-controlled patients[19,20].

Telemedicine is allowing a continuous and remote communication between patients and their health care provider and in terms of COVID-19-induced acute hyperglycemia offers the only solution in outpatient glycemic management. In this way, consulting a patient on timely ketone screening and suitable actions could prevent development of ketosis and diabetic ketoacidosis and relive a burden on hospitals or at least ensure apt emergency room visits[21].

Recently, two case reports were published, one adult and the other pediatric, where telemedicine was effectively applied in all aspects of type 1 diabetes management, consultation, education, and monitoring through available software to generate ambulatory glucose profiles and using a combination of e-mail, Internet via Zoom, and telephone calls[22].

The major obstacle in telemedicine implementation are technical support issues and government reimbursement policies, which differ by country. Structured background for integration and reimbursement in most countries is missing. There are two options presented, one involving private providers depending on private insurance and the other based on free applications such as WhatsApp, Skype, or Zoom that are not in accordance with health data privacy conditions and are not an integrated part of health care registries[23]. In most countries, health insurance covers the costs of technical devices in the management of type 1 diabetes, which is not the case for type 2 diabetes. Precisely for this reason telemedicine is the most widely used in long standing type 1 diabetes management but also has potential in new onset type 1 diabetes and prevention of acute complications, especially important in the COVID-19 era (Figure 1).

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Figure 1 Essential requirements for successful implementation of telemedicine in the management of type 1 diabetes. CGM: Continuous glucose monitoring; FGM: Flash glucose monitoring.

Downloading data from devices is a weak link in wider implementation of telemedicine because the older population is not skilled enough or do not have technical support necessary to prepare reports for consults. Unfortunately, this population in particular could benefit the most from remote consulting due to vulnerability to SARS-CoV-2 and other infections, walking disabilities, and poorer socioeconomic status. In addition, the majority of those patients do not have smart phones and do not use the internet frequently. Thus, improvements in user support services are necessary at this stage to resolve issues in service delivery[5].

The main question is could telemedicine replace face-to-face visits? One could argue that even if we have necessary data regarding glycemic management, we still could not perform a physical exam in order to evaluate cardiovascular health or polyneuropathy. It should be emphasized that telemedicine in retinopathy screening has been long recognized[24]. On the other hand, telemedicine and constant contact with patients enables physicians to act in time, to give advice regarding hypo- or hyperglycemia, adjust insulin doses, and provide proper actions in case of emergencies.

The potential in cost reductions and advancements of health care are plausible and supported by a recently published meta-analysis including 8 studies investigating a role of telemedicine in the COVID-19 pandemic confirming that telehealth care improves accessibility of health services[25]. However, there are no definite reports on long-term outcomes or cost reduction necessary for creating government health care policies as well as building technical infrastructure.