Acta Virologica Vol.56, No.4, p.337-342, 2012

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ISSN 0001-723X
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Acta Virologica Vol.56, No.4, p.337-342, 2012
Title: A peptide vaccine based on a B-cell epitope on the VP1 protein of enterovirus 70 induces a strong antibody response
Author: KEE-BUM PARK, BYUNG-KWAN LIM, MICHAEL B. YE, SOO-YOUNG CHUNG, JAE-HWAN NAM

Abstract: Enterovirus 70 (EV70) is the causative agent of acute hemorrhagic conjunctivitis (AHC), for which no effective vaccine is available. This study revealed a high reactivity of the N-terminal region of EV70 VP1 (VP1-1) with an anti-EV70 mouse serum. The analysis of overlapping synthetic peptides of VP1-1 identified a B-cell epitope in this region. The E-peptide (14-ANTVESEIKAELGVI-28) showing the highest reactivity with the anti-EV70 serum induced neutralizing antibodies in mice and reduced the virus titer in the eyes, suggesting that it is a candidate vaccine against AHC caused by EV70.

Keywords: enterovirus 70; AHC; B-cell epitope; peptide vaccine

Year: 2012, Volume: 56, Issue: 4	Page From: 337, Page To: 342
doi:10.4149/av_2012_04_337
Price: 12.00 €

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