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CC BY-NC-ND 4.0 · World J Nucl Med 2021; 20(02): 202-204
DOI: 10.4103/wjnm.WJNM_75_20
Case Report

Hot-clot artifact in the lung parenchyma on 18F-fluorodeoxyglucose positron emission tomography/computed tomography mimicking malignancy with a homolateral non-small cell lung cancer

Yacine El Yaagoubi
Department of Nuclear Medicine, NCT+ Clinic, Saint-Cyr-Sur-Loire, France
,
Caroline Prunier-Aesch
Department of Nuclear Medicine, NCT+ Clinic, Saint-Cyr-Sur-Loire, France
,
Laurent Philippe
Department of Nuclear Medicine, NCT+ Clinic, Saint-Cyr-Sur-Loire, France
,
Philippe Laplaige
1   Department of Oncology, Blois Polyclinic, La Chaussée-Saint-Victor, France
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Abstract

18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (CT) is an important tool widely used in the oncology to stage and restage various malignancies. Intense focal FDG uptake in the lung parenchyma associated with the absence of anatomical lesion detected on CT can be explained by a lung microembolism, known as hot-clot artifact. We report, to the best of our knowledge, the first case describing a single hot-clot artifact located in the same lung as a histologically proven non-small cell lung cancer.

Keywords

18F-fluorodeoxyglucose - hot-clot artifact - lung cancer - positron emission tomography

Financial support and sponsorship

Nil.




Publication History

Received: 29 June 2020

Accepted: 30 June 2020

Article published online:
24 March 2022

© 2021. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Shreve PD, Anzai Y, Wahl RL. Pitfalls in oncologic diagnosis with FDG PET imaging: Physiologic and benign variants. Radiographics 1999;19:61-77.
  • 2 Karantanis D, Subramaniam RM, Mullan BP, Peller PJ, Wiseman GA. Focal F-18 fluoro-deoxyglucose accumulation in the lung parenchyma in the absence of CT abnormality in PET/CT. J Comput Assist Tomogr 2007;31:800-5.
  • 3 Hartman T. Pearls and Pitfalls in Thoracic Imaging: Variants and Other Difficult Diagnoses. New York: Cambridge University Press; 2011. p. 198-201.
  • 4 Sanchez-Sanchez R, Rodriguez-Fernandez A, Ramirez-Navarro A, Gomez-Rio M, Ramos-Font C, Llamas-Elvira JM. PET/CT: focal lung uptake of 18F-fluorodeoxyglucose on PET but no structural alterations on CT. Rev Esp Med Nucl 2010;29:131-4.
  • 5 Farsad M, Ambrosini V, Nanni C, Castellucci P, Boschi S, Rubello D, et al. Focal lung uptake of 18F-fluorodeoxyglucose (18F-FDG) without computed tomography findings. Nucl Med Commun 2005;26:827-30.
  • 6 Fathinul Fikri A, Lau W. An intense F-FDG pulmonary microfocus on PET without detectable abnormality on CT: A manifestation of an iatrogenic FDG pulmonary embolus. Biomed Imaging Interv J 2010;6:e37.
  • 7 Ha JM, Jeong SY, Seo YS, Kwon SY, Chong A, Oh JR, et al. Incidental focal F-18 FDG accumulation in lung parenchyma without abnormal CT findings. Ann Nucl Med 2009;23:599-603.
  • 8 Hany TF, Heuberger J, von Schulthess GK. Iatrogenic FDG foci in the lungs: A pitfall of PET image interpretation. Eur Radiol 2003;13:2122-7.
  • 9 Ozdemir E, Poyraz NY, Keskin M, Kandemir Z, Turkolmez S. Hot-clot artifacts in the lung parenchyma on F-18 fluorodeoxyglucose positron emission tomography/CT due to faulty injection techniques: Two case reports. Korean J Radiol 2014;15:530-3.