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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(S 01): S133-S135
DOI: 10.4103/ijmpo.ijmpo_189_17
Case Report

Acute Pancreatitis Caused by Pemetrexed, Carboplatin, and Gemcitabine in a Patient with Lung Cancer: A Rare Case Report

Vishal Kulkarni
Departments of Medical Oncology, HCG, Bengaluru, Karnataka, India
,
BJ Srinivasa
Departments of Medical Oncology, HCG, Bengaluru, Karnataka, India
,
PK Kiran
Departments of Medical Oncology, HCG, Bengaluru, Karnataka, India
,
Vinu Sarathy
Departments of Medical Oncology, HCG, Bengaluru, Karnataka, India
,
S Shivakumar Swamy
Departments of Radiodiagnosis, HCG, Bengaluru, Karnataka, India
,
Radheshyam Naik
Departments of Medical Oncology, HCG, Bengaluru, Karnataka, India
› Institutsangaben Financial support and sponsorship Nil.
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Abstract

Drug-induced pancreatitis is reported as one of the less common causes of acute pancreatitis. Many drugs such as sulfonamides, estrogens, tetracyclines, valproic acid, antiretroviral drugs, some chemotherapy drugs such as azathioprine, and 6 MP are known to cause acute pancreatitis. We report a case of acute pancreatitis following administration of chemotherapy for non-small cell lung cancer (NSCLC). The patient was diagnosed to have NSCLC (histologically proven adenocarcinoma). After thorough evaluation including radiological investigations consisting of a positron-emission tomography computed tomography scan, he was staged as a Stage III B NSCLC. As per protocol, he was started on combination chemotherapy with pemetrexed and carboplatin. After 2 weeks of chemotherapy, he developed acute pancreatitis which was managed conservatively. He was administered different drug combination during the next cycle involving gemcitabine and carboplatin. However, he developed recurrent acute pancreatitis which was managed conservatively. He was then referred to the radiotherapy department as it was deemed that he is at risk of recurrent episodes of pancreatitis if further cycles of chemotherapy are continued.

Keywords

Acute pancreatitis - carboplatin - chemotherapy - gemcitabine - pemetrexed


Publikationsverlauf

Artikel online veröffentlicht:
24. Mai 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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