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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2009; 30(02): 80-83
DOI: 10.4103/0971-5851.60053
CASE REPORT

Endometrioid endometrial adenocarcinoma in a premenopausal woman with multiple organ metastases

Nirmala Srikantia
Department of Radiotherapy, M S Ramaiah Medical College and Hospital, MSRIT Post, Bangalore - 560085, India
,
B Rekha
Department of Radiotherapy, M S Ramaiah Medical College and Hospital, MSRIT Post, Bangalore - 560085, India
,
A.G. Rajeev
Department of Radiotherapy, M S Ramaiah Medical College and Hospital, MSRIT Post, Bangalore - 560085, India
,
Suman Kalyan
Department of Radiotherapy, M S Ramaiah Medical College and Hospital, MSRIT Post, Bangalore - 560085, India
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Abstract

Endometrial adenocarcinoma is the third common malignancy of the female genital tract occurring most often in the postmenopausal age group. High tumor grade, advanced surgical stage, and lymphovascular space invasion are implicated as poor prognostic factors for dissemination of disease. We present an unusual case of endometrial adenocarcinoma in a premenopausal woman with simultaneous metastases in brain, liver, skin and skeletal system, within one month of completion of treatment. The role of adjuvant/concurrent chemotherapy in addition to radiotherapy in high risk cases is discussed along with the review of literature.

Keywords

Adjuvant chemotherapy - endometrial carcinoma - multiple organ metastases


Publication History

Article published online:
19 November 2021

© 2009. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Society AC: Cancer Statistics 2006. Available from: http://www.cancer.org/downloads/STT/CAFF2006PWSecured.pdf last accessed on 15/01/2010.
  • 2 Kushner DM, Lurain JR, Fu TS, Fishman DA. Endometrial adenocarcinoma metastatic to the scalp: case report and literature review. Gynecol Oncol 1997;65:530-3.
  • 3 Neto AG, Gupta D, Broaddus R, Malpica A. Endometrial endometrioid adenocarcinoma in a premenopausal woman presenting with metastasis to bone: a case report and review of the literature. Int J Gynecol Pathol 2002;21:281-4.
  • 4 Gien LT, Kwon JS, D′Souza DP, Radwan JS, Hammond JA, Sugimoto AK, et al. Brain metastases from endometrial carcinoma: A retrospective study. Gynecol Oncol 2004;93:524-8.
  • 5 William E Winter III, Jim A Gosewehr: Uterine Cancer. E Medicine. [updated on 2006 May 19].
  • 6 NCCN Practice guidelines in Oncology. Vol. 1. 2008.
  • 7 Santin AD, Bellone S, O′Brien TJ, Pecorelli S, Cannon MJ, Roman JJ. Current treatment options for endometrial cancer. Expert Rev Anticancer Ther 2004;4:679-89.
  • 8 Uehara T, Katsumata N. Combination chemotherapy with paclitaxel and carboplatin for endometrial cancer. Gan To Kagaku Ryoho 2008;35:1488-94.
  • 9 Aoki Y, Watanabe M, Amikura T, Obata H, Sekine M, Yahata T, et al. Adjuvant chemotherapy as treatment of high-risk stage I and II endometrial cancer. Gynecol Oncol 2004;94:333-9.
  • 10 Greven K, Winter K, Underhill K, Fontenesci J, Cooper J, Burke T, et al. Preliminary analysis of RTOG 9708: adjuvant postoperative radiotherapy combined with cisplatin/paclitaxel chemotherapy after surgery for patients with high-risk endometrial cancer. Int J Radiat Oncol Biol Phys 2004;59:168-73.
  • 11 Gadducci A, Cavazzana A, Cosio S, DI Cristofano C, Tana R, Fanucchi A, et al. Lymph-vascular space involvement and outer one-third myometrial invasion are strong predictors of distant haematogeneous failures in patients with stage I-II endometrioid-type endometrial cancer. Anticancer Res 2009;29:1715-20.