Calciphylaxis in chronic renal failure: An approach to risk factors

We present a case of calcifying panniculitis due to calciphylaxis in a nontherapy compliance 65-year-old man suffering from chronic renal failure. Calciphylaxis, a life threatening condition, is characterized by high calcium × phosphate product, presence of calcium crystals in the skin and secondary hyperparathyroidism. The clinical presentation includes painful firm plaques, which could progress to nonhealing ulcers. A review of literature is given with emphasis on identification of risk factors and early diagnosis.


Introduction
Patients with an edematous painful leg are frequently referred to internists.Differential diagnosis includes a wide range of diseases, such as deep venous thrombosis and infections.Herein, we report a patient with chronic renal failure (CRF) suffering from bilateral painful warm, swollen legs that appeared to be caused by an insufficient dialysis dose, and its early diagnosis and timely treatment prevented serious complications.Although this condition is known to nephrologists, it remains under recognized by other physicians including internists and general practitioners.

Case Report
A 65-year-old Indonesian man was referred to our clinic because of progressively painful plaques in the skin of his legs during a 3-week period.The patient had been diagnosed with diabetes mellitus type II at age 38 and hypertension at age 52.He had developed chronic renal failure and had begun maintenance continuous ambulatory peritoneal dialysis (CAPD) at the age of 62. Peritoneal dialysis was hampered by a poor adherence to the prescribed treatment protocol, a poor compliance to the prescribed medication and by an excessive oral fluid intake of about 5 L/day to which he had been used to Skin biopsy specimens were taken from the plaques demonstrating calcium depositions involving the intima of small arteries and venules.The specimens reveals extravascular soft tissues calcifications, associated with lobular panniculitis and adipose tissue necrosis [Figure 3a].The presence of the calcium-salt-depositions was confirmed by a specific calcium-staining (von Kossa stain) [Figure 3b].On basis of this findings and elevated serum Ca × P product, the diagnosis 'calciphylaxis' was made.The first step of therapy was normalization of Ca × P product serum level.For this reason, calcitrol and calcium acetate were discontinued and low calcium dialysate (calcium concentration 1.25 mEq/L) was instituted.Furthermore, the dialysis-dose was increased (from 8 l dialysate/day to 12 l/day).Within a few days, the results of the laboratory findings greatly improved and within a week, the legs became less inflamed and painful and patient became ambulatory.In that week, corticosteroid-therapy was considered to decrease the

Discussion
[3] It is estimated to occur in 1-4% of CRF-patient who are subjected to hemodialysis each year. [4]e clinical presentation includes primary lesions as painful firm plaques or subcutaneous nodules which progress to secondary lesions as non-healing ulcers.
This process can result in tissue necrosis, gangrene and sepsis. [3,5]The lesion manifests itself characteristically in lower extremities particularly the thighs and buttocks, but less frequently in abdomen, upper extremities and penis. [1]alciphylaxis was first described by Selye, in 1962 as a local or systemic calcium deposition in an experimental animal model.He postulated that deposition are induced by exposure to the "challenging" agents such as local traumas or metal salt after a phase of developing systemic "sensitization" to one or several agents such as parathyroid hormone, vitamin D or a diet high in calcium and phosphate. [6,7]Although the pathogenesis of calciphylaxis is poorly understood, Liach et al. outlines three pathogenic factors presence of uremic milieu in concert with a high Ca × P product; elevated content of calcium salt in the skin and presence of high parathyroid hormone (PTH) level. [8]Lab studies of our case confirm contribution of above mentioned parameters to develop calciphylaxis.
[Table 1] Several risk factors in CRF patient appear to be associated with increase of Ca × P product level which is shown in Table 2. Obesity, hypoalbuminemia, decreased local or systemic blood flow, pre-existing disturbance of coagulation and trauma are reported to be predisposing factors in developing secondary lesions. [1,4,9,10]condary hyperparathyroidism, an important risk factor is present commonly in the setting of CRF.Recent studies revealed that this condition develops in response to hyperphosphatemia, low calcium level and deficit of calcitrol. [8]Hyperparathyroidism is a serious problem in dialysis patient which accelerates bone turnover and consequently phosphate and calcium efflux. [11]Hence, early control of secondary hyperparathyroidism is essential.Calcitrol administration was considered in the past as an effective treatment for the treatment of secondary hyperparathyroidism, but this implies two relevant side effects including hypercalcemia and hyperphosphatemia. [12]erefore, administration of calcitrol was stopped in our case.
Over the past years are several vitamin D analogs developed which can inhibit PTH secretion without promoting of hyperphosphatemia and hypercalcemia.Clinical trials to determine long term results of using these agents in dialysis patient are still in progress. [13]6] Parathyroidectomy in patient with high PTH level appears to ameliorate clinical presentation, but there is no strong evidence regarding improved survival. [4] addition, Block et al. showed that hyperphosphatemia occurs in 50% of dialysis population. [13]The most common causes of hyperphosphatemia consist of high dietary intake of phosphate and inadequate dialysis. [17]With non compliance as in our case, hyperphosphatemia may be a reflection of insufficient dialysis. [12]This necessitated application of more intensive dialysis program with low calcium dialysate (0.00 to 2.00 mEq/L).Furthermore, restriction of oral intake of calcium and phosphate was considered.The use of non calcium phosphate binders such as Sevelamer are advocated in such patient.A recent study showed that use of sevelamer in CRF patient is associated with significant survival benefits compared to  calcium containing phosphate binders. [13]Inadequately dose of sevelamer before admission of patient in our clinic contributed to the high serum phosphate.This reason increase dose in the sevelamer to 4.8 gm/day.
0] Though after application of several measures, the clinical presentation of our patient was significantly improved, the long-term prognosis in such patient remains poor.Fine et al. demonstrated a mortality rate of 33% at six months in patient who presented only plaques which increased to above 80% in those patients developing ulceration. [3]

Conclusion
With the increasing number of patients undergoing dialysis, calciphylaxis is no longer rare.It is important for the clinician to be aware of this entity, because prompt diagnosis and treatment may halt progression of disease and minimize mortality rate.Avoidance or correction of risk factors described in this study is the first step to prevent calciphylaxis in CRF patients.

Figure 1 :
Figure 1: Multiple painful indurated plaques on both lower extremities Figure 2a: Soft tissue x-ray showed increased density on medial aspect of right lower leg inflammatory response but not instituted because of lack of scientific evidence for this measure.

Figure 3a :
Figure 3a: H and E stain of skin lesions showed lobular dystrophic calcified panniculitis and adipose tissue necrosis

Table 2 : Risk factors for calciphylaxis
High intake of calcium and phosphate Use of calcium-containing phosphate binders Use of calcitrol Inadequate dialysis dose Use of dialysate with high calcium concentration Secondary hyperparathyroidism Obesity Hypoalbuminemia