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Korean Journal of Anesthesiology 1993;26(6):1207-1213.
DOI: https://doi.org/10.4097/kjae.1993.26.6.1207   
Comparative Study of Ondansetron versus Placebo to Prevent Postoperative Nausea and Vomiting in those Undergoing Abdominal Surgery.
Kwang Min Kim, Hyun Soo Kim, Hyun Choi, Soon Eun Park, Jung Bae Youn, Byung Jo Choi
Department of Anesthesiology, Hallym University Medical College, Seoul, Korea.
Abstract
Postoperative emesis is still a troublesome problem in patients undergoing general anesthesia. We compared the efficacy and safety of ondansetron, a selective antagonist of serotonin 5HT3 receptors, within the 24hours postoperative period. Forty patients between the ages of 12 and 75 and ASA class I-III, having general anesthesia, undergoing elective abdominal surgery (except gynecologic surgery) were assigned to one of two treatment groups according to uncontrolled parallel comparative study design. A standard anesthetic technique consisting of thiopental-atracurium for induction and N2O-Enflurane for maintenance of anesthesia was used. The data showed that intravenous ondansetron 4mg i.v. before induction was significantly more effective in preventing emesis (n=20, 85%) than placebo (n=20, 60%). Nausea severity scores were also significantly decreased from 1.5+/-0.6 (mean+/-SE) in placebo group to 0.30.1 in ondansetron group (p<0.05). All patients receiving of ondansetron 4mg intravenously tolerated their treatment well, without any special adverse events. Conclusion; Ondansetron(4mg) given intravenously before induction to prevent postoperative nausea and vomiting in patients undergoing elective abdominal surgery was effective and safe.
Key Words: ondansetron; postoperative; nausea; vomiting


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