Korean Circ J. 2002 Sep;32(9):773-780. Korean.
Published online Sep 30, 2002.
Copyright © 2002 The Korean Society of Circulation
Original Article

The Long-Term Clinical Effects of Heparin-Coated Coronary Stent

Hyung Wook Park, Myung Ho Jeong, Ok Young Park, In Soo Kim, Myung Ja Choi, Seung Hyun Lee, Young Joon Hong, Weon Kim, Ju Han Kim, Woo Suk Park, Jay Young Rhew, Young Keun Ahn, Jeong Gwan Cho, Dong Lyun Cho, Jong Chun Park and Jung Chaee Kang
    • The Heart Center of Chonnam University Hospital, Korea.
    • Faculty of Applied Chemical Engineering of Chonnam National University, Korea.
    • The Research Institute of Medical Sciences, Chonnam National University, Gwangju, Korea.

Abstract

Background and Objectives

A heparin-coated stent has been reported to be effective in the prevention of restenosis in a porcine model. The aim of this study was to compare the long term effects of heparin-coated and bare stents in patients who underwent percutaneous coronary intervention (PCI), with regard to the clinical and angiographic outcomes.

Subjects and Methods

Thirty patients who underwent PCI at Chonnam National University Hospital between July 1999 and December 2000 were randomly assigned into two groups; Group I had control bare stents (n=15, 15 lesions, 59±12 years, 13 males) and Group II heparin coated stents (n=15, 15 lesions, 59±11 years, 14 males). Six months following stenting, follow-up coronary angiograms were performed in 24 (80%) patients. The average follow-up period was 22±6 months.

Results

The initial clinical and angiographic characteristics were no different between the two groups. The reference diameters (Group I; 2.84±0.57 mm, II; 3.34±0.57 mm), minimal luminal (Group I; 2.37±0.60 mm, II; 2.60±0.59 mm) and diameter stenosis (Group I; 16.8±8.8%, II; 22.6±8.6%) following stenting, were no different between the two groups. Subacute stent thrombosis was observed in 1 patient (6.7%) of Group I. On follow-up coronary angiograms, the reference (group I; 2.46±0.34 mm, group II; 2.70±0.43 mm), minimal luminal diameters (group I; 1.47±0.59 mm, group II; 1.64±0.80 mm) and diameter stenosis (group I; 39.4±25.1%, group II; 40.8±26.1%) diameters were also no different, and restenosis was observed in 3 (25%) patients of each group. One cardiac death and 3 target vessel revascularizations were observed in each group during follow-up.

Conclusion

The heparin-coated coronary stents were not effective in the prevention of coronary stent restenosis.

Keywords
Coronary diseases; Heparin; Stents; Restenosis


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