Evaluation of Cytotoxic Activity of d-Metal Complexes with Hydrazone Ligands

M. Lazić; Siniša  Radulović; Tamara R. Todorović; D.M. Sladić; Ž. Tešić; K.K. Andjelković

doi:10.4028/www.scientific.net/MSF.518.513

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HomeMaterials Science ForumMaterials Science Forum Vol. 518Evaluation of Cytotoxic Activity of d-Metal...

Evaluation of Cytotoxic Activity of d-Metal Complexes with Hydrazone Ligands

Abstract:

Cytotoxic activity of four series of coordinated complexes of Zn(II) and Fe(II) with hydrazone/hydrazide ligands against HeLa and B16 cells was evaluated. The ligands N’,N'2- bis[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (H2L1) and N’,N'2-bis[(1E)-1-(2-pyridyl) ethylidene]propanedihydrazide (H2L2) and their Zn(II) complexes showed IC50 values in the low micromolar range, while the other ligands and complexes were less active or inactive.

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Periodical:

Materials Science Forum (Volume 518)

Pages:

513-518

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.518.513

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Online since:

July 2006

Authors:

M. Lazić, Siniša Radulović, Tamara R. Todorović, D.M. Sladić, Ž. Tešić, K.K. Andjelković

Keywords:

Cytotoxic Activity, Hydrazone, Transition Metal Complexes

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