Distribution & Access For Publication Downloads News About Us Contact Us
Paper Titles
Morphology and Mechanical Properties of a Composite Coating by Electrostatic Dry Spray Method
p.168
Effect of Cold Plasma on the Levels Mineral Blood Components In Vivo
p.177
Preparation and Physical Properties of PCL-Metoprolol Tartrate Electrospun Nanofibers as Drug Delivery System
p.183
Evaluation of Surface Roughness of Some Biomedical Titanium Alloys by Pack Cementation Coating
p.189
Nanoemulsions Drug Delivery System: Preparations Techniques In Vitro Characterization and Pharmaceutical Application
p.203
Characterization of Thermal Inertia and Footprint Carbon of Clay-Wool, Clay-Cork, and Clay-Plastic Composites
p.213
Phase Change Materials Technologies Review and Future Application in Lebanon: Part 1
p.228
Influence of the Kind and the Shape of Insulating Materials on the Mechanical Properties of the Composites Plaster- Granular Cork and Plaster- Fiber Alpha
p.241
Phase Change Materials Technologies Review and Future Application in Lebanon: Part II
p.256

Nanoemulsions Drug Delivery System: Preparations Techniques In Vitro Characterization and Pharmaceutical Application

Article Preview

Abstract:

Nano-emulsions are a novel drug delivery system, in which mix two immiscible liquids, normally oil and water with the addition a proper surfactant and co-surfactant to obtain a single uniform phase, in many cases must be used more than one surfactant to improve the stability of nanoemulsion, in this survey consideration is focused to provide brief information about the formulation, a strategy of preparation, characterization procedure, evaluation parameter as particle size, polydispersity, drug content, zeta potential, and different application of nanoemulsion, it is thermodynamically unsteady colloidal dispersion systems having an average droplet size which ranges from 10 to 200 nm, the decrease in a bead size to nanoscale leads to alter in physical properties such as uncommon elastic behavior and optical transparency and get better bioavailability and good targeting. The formulation of O/W nanoemulsion where hydrophobic drugs are dissolved within the oil phase consider the common approach of nanoemulsion utilization in biomedical application. The essential thought behind these formulations is that nanodroplets act as a medium to transport hydrophobic drugs. The advantage of nanodroplets when compared to the bigger droplet sized emulsions is the upgraded stability and progressed pharmacological activity nanoemulsions have broad applications in numerous areas other than pharmaceutics, like in cosmetics, nourishment and other applications owing to many benefits of nanoemulsion as higher stability versus coalescence, lack of harmfulness or irritant effect, minimal viscosity, good appearance, as well as the flexibility of formulation like liquids, creams in addition to sprays.

You might also be interested in these eBooks
Advanced Materials and Application Technologies View Preview

Info:

Periodical:

Key Engineering Materials (Volume 886)

Pages:

203-210

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.886.203

Citation:

Cite this paper

Online since:

May 2021

Authors:

Rafid A. Rasool Alobaidy, Nawal A. Rajab, Adawiya J. Haider*

Keywords:

Nano System, Nanodroplets, Nanoemulsions, Polydispersity, Solvent Evaporating, Ultrasonication

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

* - Corresponding Author

References

[1] T.G. Mason, J.N. Wilking, K. Meleson, C.B. Chang, and S.M Graves., Nanoemulsions: Formation, structure, and physical properties, (2016); (March).

Google Scholar

[2] E.A Ostrosky, P.A Rocha-filho, and Veríssimo L.M., Production and Characterization of Cosmetic Nanoemulsions Containing Opuntia ficus-indica, ( 2015); 2492–509.

DOI: 10.3390/molecules20022492

Google Scholar

[3] A. Kumar, CK. Dixit, Methods for characterization of nanoparticles. In: Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids,( 2017). p.44–58.

DOI: 10.1016/b978-0-08-100557-6.00003-1

Google Scholar

[4] J.J Wang., CF Hung, C.H Yeh., J.Y. Fang, "he release and analgesic activities of morphine and its ester prodrug, morphine propionate, formulated by water-in-oil nanoemulsions, (2008); 16(4): 294–301.

DOI: 10.1080/10611860801900090

Google Scholar

[5] SN, Kale, SL. Deore, Emulsion micro emulsion and nano emulsion: A review,. Syst Rev Pharm. (2016); 8(1): 39–47.

DOI: 10.5530/srp.2017.1.8

Google Scholar

[6] T.Delmas, P.Poulin, ME.Cates, How To Prepare and Stabilize Very Small Nanoemulsions, (2011); 27(16): 1683–92.

DOI: 10.1021/la104221q

Google Scholar

[7] Adawiya J.Haider, Riyad Al-Anbari Habi M. Sami, Mohammed J.Haider, Enhance Preparation and Characterisation of Nickel-Oxide as SelfCleaning Surfaces, Energy Procedia 157 (2019) 1328-1342.

DOI: 10.1016/j.egypro.2018.11.298

Google Scholar

[8] TH. Nikam, MP. Patil, SS. Patil, GP. Vadnere, S.Lodhi, Nanoemulsion: A brief review on development and application in Parenteral Drug Delivery, Adv Pharm J.(2018); 3(2):43–54.

DOI: 10.31024/apj.2018.3.2.2

Google Scholar

[9] KB.Sutradhar, Nanoemulsions: increasing possibilities in drug delivery, (2013); 5(2): 97-110.

Google Scholar

[10] J.D. Colmenares, Development of Nanoemulsion-based Delivery Systems for Evaluation of Triglycerides Bioactivity in Caernohabditis Elegans Submitted to the Graduate School of the (2015); (November).

Google Scholar

[11] N. Saleh, Z. Yousaf Chapter 3. Tools and techniques for the optimized synthesis, reproducibility and scale up of desired nanoparticles from plant derived material and their role in pharmaceutical properties, Elsevier Inc.; (2018), 85–132p.

DOI: 10.1016/b978-0-12-813629-4.00003-6

Google Scholar

[12] SG. Frank, Book Review: Physical Pharmacy: Physical Chemical Principles in the Pharmaceutical Sciences, 3rd Ed. Vol.18, Drug Intelligence & Clinical Pharmacy. (1984) 663-664 p.

DOI: 10.1177/106002808401800740

Google Scholar

[13] R.Mun, Application of Nanoemulsions in the Synthesis of Nanoparticles, (2018) 477–515 p.

Google Scholar

[14] A. Gupta, Nanoparticles for Biomedical Applications. Elsevier Inc.; (2020) 371– 384 p.

Google Scholar

[15] D.J Mc Clements, Nano-emulsions versus micro-emulsions: terminology, differences, and similarities., Soft matter 8.6 (2012): 1719-1729.

Google Scholar

[16] N.Haziqah, C.Marzuki, R.A Wahab., M.A Hamid., An overview of nanoemulsion : concepts of development and cosmeceutical applications. Biotechnol Biotechnol Equip (2019); 33(1): 779–97.

DOI: 10.1080/13102818.2019.1620124

Google Scholar

[17] MN. Yukuyama, D.M, Ghisleni Pinto TJA, NA Bou-Chacra., Process selection and application in cosmetics - A review. Int J Cosmet Sci. (2016); 38(1):13–24.

DOI: 10.1111/ics.12260

Google Scholar

[18] F. Lallemand, P. Daull, S. Benita, R. Buggage, J. Garrigue, the Cationic Nanoemulsion, Novasorb. (2012).

DOI: 10.1155/2012/604204

Google Scholar

[19] N.Sharma, Preparation and Optimization of Nanoemulsions for targeting Drug Delivery. (2017); (July).

Google Scholar

[20] KO Aboalnaja, S. Yaghmoor, TA Kumosani, DJ.McClements, Utilization of nanoemulsions to enhance bioactivity of pharmaceuticals, supplements, and nutraceuticals, Expert Opin Drug Deliv. (2016); 13(9):1327–36.

DOI: 10.1517/17425247.2016.1162154

Google Scholar

[21] R. Arora, G. Aggarwal, SL. Harikumar, K. Kaur, Nanoemulsion Based Hydrogel for Enhanced Transdermal Delivery of Ketoprofen. , (2014).

DOI: 10.1155/2014/468456

Google Scholar

[22] Y. Singh, JG. Meher, K. Raval, F.A. Khan, M. Chaurasia, NK. Jain, et al. Nanoemulsion: Concepts, development and applications in drug delivery. J Control Release (2017); 252:28–49.

DOI: 10.1016/j.jconrel.2017.03.008

Google Scholar

[23] Safaa I. AL-Saedi, Adawiya J. Haider, Asama N. Naje, Nathalie Bassil, Improvement of Li-ion batteries energy storage by graphene additive, Energy Reports 6 (2020) 64-71.

DOI: 10.1016/j.egyr.2019.10.019

Google Scholar

Scientific.Net is a registered brand of Trans Tech Publications Ltd
© 2024 by Trans Tech Publications Ltd. All Rights Reserved