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Rheological Studies of an Injectable Radiopaque Hydrogel for Embolization of Abdominal Aortic Aneurysms

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Abstract:

Several embolizing agents have been tested for minimally invasive treatment of intracranial aneurysms, and more recently to prevent or treat persistent blood flow (endoleaks) in abdominal aortic aneurysms. However, frequent recurrence of endoleaks was seen in most studies, suggesting that current embolization agents are not satisfying yet. Here we report rheological studies of a radiopaque chitosan hydrogel as an embolizing agent. The aim is to provide an agent that would be visible during x-ray based guided interventions. In this study, a commercial contrast agent (iopamidol) was associated to chitosan at different concentrations and its influence on the rheological behavior of chitosan thermogel was evaluated. The resulting hydrogels have a homogenous coherent structure. The addition of iopamidol leaded to an initially more viscous solution. To have a good visibility of hydrogel via x-ray, an optimum iopamidol concentration of 20% v/v was chosen. The addition of 20% v/v iopamidol increased the gelation time. The use of a high βGP concentration constitutes a solution to overcome the slowing down of gelation by 20% v/v iopamidol. Formulations containing around 16-20% βGP provides viscous solutions which rapidly gel and could be promising injectable radiopaque hydrogels for embolization.

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Periodical:

Advanced Materials Research (Volume 409)

Pages:

129-135

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.409.129

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Online since:

November 2011

Authors:

Ahmed Fatimi, Jean Michel Coutu, Guy Cloutier, Sophie Lerouge

Keywords:

Abdominal Aortic Aneurysm, Chitosan, Embolization, Radiopaque Hydrogel

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