Fabrication of Shellac-Zein Based Matrix Tablet as a Carrier for Controlling of Drug Release

Noppadol Chongcherdsak; Direk Aekthammarat; Teerayuth Prathumchat; Chutima Limmatvapirat; Sontaya Limmatvapirat

doi:10.4028/www.scientific.net/AMR.1060.50

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1060Fabrication of Shellac-Zein Based Matrix Tablet as...

Fabrication of Shellac-Zein Based Matrix Tablet as a Carrier for Controlling of Drug Release

Abstract:

The aim of research was to fabricate shellac-zein composite polymer-based matrix tablets by using theophylline as a model drug. The tablets were prepared by direct compression process. The initial weight and hardness of tablets were controlled within the range of 300±5 mg and 60±10 N, respectively. The tablets were annealed at 80 °C for 24 h and kept in the ambient temperature before evaluation. Drug release profile and kinetics of drug release in 0.1 N HCl and buffer pH 6.8 were investigated. The result showed that the annealing process and shellac:zein ratio, affected drug release characteristic in both media.The delayed released in acid medium of formulation containg shellac-zein composite polymer at the ratio from 30:70 was extended to over 120 min. In addition, the more sustained drug released in buffer was observed after increasing shellac:zein ratio. The good acid resistance of shellac and the swollen characteristic of zein in buffer might be a good explanation for the specific release. For the analysis of drug release data, drug release profiles were fitted into Higuchi model suggesting that the main mechanism of drug release from matrix tablets was super case II transport.