Fabrication of Nano-Fibrous Poly(L-Lactic Acid) Scaffold Enhanced by Silane Modified Chitosan Fibers

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Abstract:

In this study, A PLLA/silane modified chitosan fiber composite scaffold was sucessfully prepared using thermal induced phase separation method. The PLLA was chemically coupled with chitosan fiber surface using γ-methacryloxypropyl-trimethoxysilane.The composite scaffold had a nano-fibrous PLLA matrix (fiber size 200-750 nm), an interconnective pores ((1-6 μm), high porosity (>90%). Introduced surface modified chitosan fibers into PLLA matrix, it significantly enhanced the nano-fibrous scaffold. The new nano composite scaffold is potentially a very promising scaffold for tissue engineering.

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609-612

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January 2012

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[1] Z. W. Ma, M. Kotaki, R. Inai and S. Ramakrishna: Tissue Eng. 11(2005). p.101.

Google Scholar

[2] S. Nuernberger, N. Cyran, C. Albrecht, H. Redl, V. Vécsei and S. Marlovits: Biomaterials 32(2011). p.1032.

DOI: 10.1016/j.biomaterials.2010.08.100

Google Scholar

[3] X. Liu, Y. Won and P. X. Ma: Biomaterials 21(2006). p.3980.

Google Scholar

[4] H.S. Koh, T. Yong, C.K. Chan and S. Ramakrishna: Biomaterials 29(2008). p.3574.

Google Scholar

[5] X. J. Wang, G.J. Song, T. Lou and W.J. Peng: J. Biomater. Sci.: Polym. E. 20(2009). p.1995.

Google Scholar

[6] X. J. Wang, G.J. Song and T. Lou: J. Mater Sci.: Mater. Med. 21(2010). p.183.

Google Scholar

[7] X. Li and Q. Feng: Polym. Bull. 54(2005). p.47.

Google Scholar

[8] X. Li, Q. Feng and F. Cui; Mater. Sci. Eng. C 26(2006). p.716.

Google Scholar

[9] E.P.S. Tan and C.T. Lim: Applied Physics Letters 84(2004). p.1603.

Google Scholar

[10] V. J. Chen and P.X. Ma: Biomaterials 25(2004). p.2065.

Google Scholar

[11] P. Plikk, S. Malberg and A. Albertsson: Biomacromolecules 10(2009). p.1259.

Google Scholar