Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

J.H. Lim; J.H. Park; Eui Kyun Park; Hae Jung Kim; Il Kyu Park; H.Y. Shin; Hong In Shin

doi:10.4028/www.scientific.net/KEM.361-363.119

Paper Titles

Variations in the Compression Strength of Cylindrical Samples Made of Dense Hydroxyapatite
p.103

The Differences between the Direct and Sol-Gel Syntheses of Silicon-Contained Calcium Phosphates
p.107

Montmorillonite-Added Calcium Phosphate Bioceramic Foams
p.111

Effect of Amine Additives on the Morphology of Hydroxyapatite
p.115

Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair
p.119

Techniques for Manufacturing FGM Bioceramics
p.123

BSA Adsorption on Hydroxyapatite after Thermal Treatment
p.127

Biocompatibility Evaluation of Porous Si-Containing Hydroxyapatite Derived from Coral
p.131

Qualitative and Quantitative Evaluation of Bone and Synthetic Calcium Phosphates Using Raman Spectroscopy
p.135

HomeKey Engineering MaterialsKey Engineering Materials Vols. 361-363Fully Interconnected Globular Porous Biphasic...

Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

Abstract:

An appropriate scaffold, which provides structural support for transplanted cells and acts as a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. We developed a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold by adopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bone tissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacity in rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnecting interpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity and noxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffold construct formation. Also the bone defects grafted with fully interconnected globular porous biphasic calcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findings suggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by the foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.

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Periodical:

Key Engineering Materials (Volumes 361-363)

Pages:

119-122

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.119

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Online since:

November 2007

Authors:

J.H. Lim, J.H. Park, Eui Kyun Park, Hae Jung Kim, Il Kyu Park, H.Y. Shin, Hong In Shin

Keywords:

Biphasic Calcium Phosphate Porous Scaffold, Bone Repair, Foaming Method

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