Characterization of the Harmonic Generation from Cavitating Bubbles Interacted with a Diagnostic Ultrasound in the Focal Region of High Intensity Focused Ultrasound

Min Joo Choi; Gwan Suk Kang; Dong Guk Paeng; Sung Min Rhim; Moo Ho Bae; Bajarm Zeqiri; Andrew Coleman

doi:10.4028/www.scientific.net/KEM.321-323.1123

Paper Titles

Development of a Portable and Wireless Surface EMG
p.1107

Development of an Algorithm for a PZT Ceramic Foot Pressure Sensor
p.1111

Computer-Graphics Based Analysis of Human Foot Kinematics during the Gait
p.1115

The Effects of High-Heeled Posture on COP Kinematics and Muscle Fatigue during the Balance Control of Human Body
p.1119

Characterization of the Harmonic Generation from Cavitating Bubbles Interacted with a Diagnostic Ultrasound in the Focal Region of High Intensity Focused Ultrasound
p.1123

Non-Invasive Analysis of Trabecular Microstructural and Biomechanical Properties in Obese OLETF Rats
p.1129

Ultrasonic Characterization of Thermal Distribution in Vicinity for a Cylindrical Thermal Lesion in a Biological Tissue
p.1133

A Study on the External and Internal Morphology of the Mandibular First Premolar Using a Micro-CT
p.1139

Binding Inhibition Assay Using Fiber-Optic Based Biosensor for the Detection of Foodborne Pathogens
p.1145

HomeKey Engineering MaterialsKey Engineering Materials Vols. 321-323Characterization of the Harmonic Generation from...

Characterization of the Harmonic Generation from Cavitating Bubbles Interacted with a Diagnostic Ultrasound in the Focal Region of High Intensity Focused Ultrasound

Abstract:

Harmonic image (HI) has been proposed to be promising for visualizing lesions produced by therapeutic high intensity focused ultrasound (HIFU). The study characterizes harmonics generated from the bubble cavitating at the focal region of a therapeutic HIFU field in response to a typical diagnostic ultrasound. Based on Gilmore model, it was simulated the nonlinear dynamics of the bubble being resonated at 1 MHz of the therapeutic ultrasound and driven by a typical 3.5 MHz diagnostic pulse. It was shown that harmonic generation increased with MI in a sigmoid pattern where the rapid and transient changes occurred between 0.5 and 2 in MI. For whole ranges of MI (less than 8), the sub-harmonic was the predominant in magnitudes over other harmonic bands. This reveals that, if HI is considered for improving the detection of focal legion highly cavitating caused by a HIFU field, the sub-harmonic component would be a preferred parameter rather than the 2nd harmonic which has been commonly used in current harmonic imaging.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 321-323)

Pages:

1123-1128

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.321-323.1123

Citation:

Cite this paper

Online since:

October 2006

Authors:

Min Joo Choi, Gwan Suk Kang, Dong Guk Paeng, Sung Min Rhim, Moo Ho Bae, Bajarm Zeqiri, Andrew Coleman

Keywords:

2^nd Harmonic, Bubble, Cavitation, Harmonic Imaging, High Intensity Focused Ultrasound, Legion, Sub, Ultra, Ultrasound (US)

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

References

[1] Wu F, Wang Z B, Chen W Z. et al (2004). Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: an overview, Ultrason. Sonochem., 11, 149-154.

DOI: 10.1016/j.ultsonch.2004.01.011

Google Scholar

[2] Ahn Y B, Jeong M K, Kwon S J and Choi M J. (2004). Imaging of thermally ablated tissue using an ultrasonic elastography. J. Key Engineering Materials, 270-273, 2042-(2047).

DOI: 10.4028/www.scientific.net/kem.270-273.2042

Google Scholar

[3] Choi M J. (2000). Application of ultrasound in Medicine: Therapeutic ultrasound and ultrasound contrast agent. J. Korean Society for Noise & Vibration Engineering. 10(4), 743759.

Google Scholar

[4] Choi M J (2005). Physical principles of harmonic imaging. Proc. Kor. Soc. Med. Ultrasound, 34, 291-305.

Google Scholar

[5] Shankar P M, Krishna P D and Newhouse V L. (1998). Advantages of subharmonic over second harmonic backscatter for contrast-to-tissue echo enhancement. Ultrasound in Medicine & Biology, 24(3), 395-399.

DOI: 10.1016/s0301-5629(97)00262-7

Google Scholar

[6] Akulichev V A. (1971). Pulsations of cavitation voids. In: L D Rozenberg Ed. High-Intensity Ultrasound Fields, Plenum: New York.

DOI: 10.1007/978-1-4757-5408-7_4

Google Scholar

[7] Choi M J. (1992). Theoretical aspects of high amplitude pulsed ultrasound used in lithotripsy. PhD Thesis. University of Bath, England.

Google Scholar

[8] Apfel R E and Holland C K. (1991). Gauging the likelihood of cavitation from short pulse low duty cycle diagnostic ultrasound. Ultrasound in Medicine & Biology, 17(2), 179-185.

DOI: 10.1016/0301-5629(91)90125-g

Google Scholar

[9] Leighton T G. (1994). The acoustic bubble. Academic Press: London.

Google Scholar

[10] Cohen A (1986). Biomedical Signal Processing: Vol. 1 Time and frequency domains analysis. CRC Press: Boca Raton, Florida, USA.

Google Scholar

[11] Church C C. (1995). The effects of an elastic solid surface layer on the radial pulsation of gas bubbles. J. Acoust. Soc. Am., 97(3), 1510-1521.

Google Scholar