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Combination Effects of the Antimicrobial Agents and Cinnamon Oil

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Abstract:

The use of antimicrobial combination may be interesting because it can decrease doses and side effects of antimicrobial agents. The cinnamon essential oil was examined with respect to antimicrobial modifying activity. The combination effect of antimicrobial agents (doxycycline hyclate, ciprofloxacin HCl and metronidazole) and cinnamon oil was evaluated by checkerboard method to obtain a fractional inhibitory concentration (FIC) index. The effect of metronidazole+doxycycline hyclate and metronidazole+ciprofloxacin hydrochloride combinations were additive against Staphylococcus aureus. The indifference FIC index was observed only with the doxycycline hyclate+ciprofloxacin HCl combination. Combinations of cinnamon oil and all antimicrobial agents showed the additive effects against S. aureus. These results indicated that the antimicrobial activity of cinnamon oil was generally additive to all test antimicrobial agents.

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Periodical:

Advanced Materials Research (Volume 506)

Pages:

246-249

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.506.246

Citation:

Cite this paper

Online since:

April 2012

Authors:

J. Mahadlek, Juree Charoenteeraboon, Thawatchai Phaechamud

Keywords:

Antimicrobial Agent, Cinnamon Oil, Synergy Effect

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