Injectable Supramolecular Hydrogels Self-Assembled by Polymers and Cyclodextrins for Controlled Drug Delivery

Jun Li; Xu Li; Xiping Ni; Xin Wang; Hongzhe Li; Zhi Han Zhou

doi:10.4028/www.scientific.net/KEM.288-289.117

Paper Titles

Construction of Biodegradable Multilayer Films via Layer-by-Layer Self-Assembly as Gene Delivery System
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Anti-DNA Antibody/Cationic Lipid Micelles for Plasmid DNA Gene Delivery
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Tumor Targeting of Plasmid DNA by Dextran Conjugation Based on Metal Coordination
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Preparation of DNA Hybrid Polyethersulfone Microspheres for Endocrine Disruptor Removal
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Injectable Supramolecular Hydrogels Self-Assembled by Polymers and Cyclodextrins for Controlled Drug Delivery
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Controlled Release Technology Suppresses the Progression of Disseminated Pancreatic Cancer Cells
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An Implantable Immunosuppressive Cyclosporine Drug Delivery System
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Enzyme-Resistant Starch for Oral Colon-Targeting Drug Delivery System
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Promoted Growth of Murine Hair Follicles by Controlled Release of Growth Factors from Biodegradable Hydrogel
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Injectable Supramolecular Hydrogels Self-Assembled by Polymers and Cyclodextrins for Controlled Drug Delivery

Abstract:

Of many polymeric biomaterials, hydrogels are of special importance because of their favorable biocompatibility and pertinence in delivering delicate bioactive agents such as proteins. Physical hydrogels have attracted much attention for controlled drug delivery because of the mild and aqueous conditions involved in trapping bioactive agents. This paper reviews our recent progress on developing a new class of physical hydrogels based on the supramolecular self-assembly between cyclodextrins and bioabsorbable poly(ethylene oxide) (PEO) or its copolymers. Being thixotropic, the hydrogels can be injected through needles and applied as injectable drug delivery systems. The properties of the hydrogels also can be fine-tuned with triblock copolymers where PEO segments flank hydrophobic or biodegradable segments in the middle.