Biological Behaviour of Bonelike® Graft Implanted in the Tibia of Humans

M. Gutierres; Nandyala Sooraj Hussain; A. Afonso; L. Almeida; T. Cabral; M.A. Lopes; José D. Santos

doi:10.4028/www.scientific.net/KEM.284-286.1041

Paper Titles

Surface Energies Acting at the Interfaces of Ceramics and Glasses while in Contact with Organic and Biological Liquids
p.1023

Development of an Alumina Ceramic with a Gradient of Concentration and Microstructure for the Application of Load Bearing Implants
p.1027

Clinical Outcome of Current Generation Hydroxyapatite Coated Acetabular Design
p.1033

Comparing Dynamic Hip Screw to External Fixation for Treatment of Osteoporotic Pertrochanteric Fractures: A Prospective Randomized Study
p.1037

Biological Behaviour of Bonelike^® Graft Implanted in the Tibia of Humans
p.1041

Hydroxyapatite Hip Arthroplasty in Patients under the Age of 50
p.1045

16 Year Review of Hydroxyapatite Ceramic Coated Hip Implants - A Clinical and Histological Evaluation
p.1049

A New Injectable Bone Substitute Concept (MBCP Gel ^TM): First Clinical Results in Human Maxillo-Facial Surgery
p.1053

Treatment of Pseudoarthrosis Using Tissue-Engineered Bone Graft
p.1057

HomeKey Engineering MaterialsKey Engineering Materials Vols. 284-286Biological Behaviour of Bonelike® Graft Implanted...

Biological Behaviour of Bonelike^® Graft Implanted in the Tibia of Humans

Abstract:

This paper reports the ability of Bonelike® to regenerate bone defected areas when implanted in the tibia of 3 patients (average age of 59 years) during a high tibial osteotomy (HTO) to treat medial compartment osteoarthritis of the knee. Bonelike® is a synthetic bone graft designed to mimic the inorganic composition of bone using a patent process that consists of liquid sintering hydroxyapatite in the presence of CaO-P2O5 based glass. The preliminary clinical evaluation performed showed that an intimate contact between new formed bone and Bonelike® was established (67±10 %), with no fibrous interface. Therefore, Bonelike® is a single-handedly viable osteoconductive synthetic grafting material as it has been demonstrated from the profiles of radiological, histological and scanning electron microscopy analyses for the six months implantation period.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 284-286)

Pages:

1041-1044

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.284-286.1041

Citation:

Cite this paper

Online since:

April 2005

Authors:

M. Gutierres, Nandyala Sooraj Hussain, A. Afonso, L. Almeida, T. Cabral, M.A. Lopes, José D. Santos

Keywords:

Biological Behavior, Bonelike^® Graft, Clinical Trials

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

References

[1] T.W. Bauer, G. F Muschler , Bone Graft Materials . An Overview of the Basic Science, Clin orthop Rel. Res. 371 (2000) 10-27.

Google Scholar

[2] C.R. Perry , Bone Repair Techniques, Bone Graft and Bone Graft Substitutes, Clin Orthop Rel Res. 360 (1999) 71-86.

DOI: 10.1097/00003086-199903000-00010

Google Scholar

[3] Doron I. Ilan, Amy L. Ladd, Bone graft substitutes. Operative Tech. in plastic and Reconstructive Surgery 9(4)(2003) 151-160.

DOI: 10.1053/j.otpr.2003.09.003

Google Scholar

[4] J.D. Santos, G.W. Hastings, J.C. Knowles, Sintered Hydroxyapatite Compositions and Method for the Preparation Thereof , European Patent WO 0068164.

Google Scholar

[5] M.A. Lopes, Glass reinforced hydroxyapatite composites: Structural, Physicochemical characterisation and Biological performance, PhD thesis, 1999, FEUP, University of Porto, Portugal.

Google Scholar

[6] M.B. Coventry, Osteotomy of the upper portion of the tibia for degenerative arthritis of the knee: a preliminary report. J. Bone Joint Surg. Am. 47 (1965) 984.

DOI: 10.2106/00004623-196547050-00008

Google Scholar

[7] M.A. Lopes, J.D. Santos et al. J. Biomed Mat Res 54 (2001) 463-469.

Google Scholar