Genetic Differentiation and Systematic Evolution of Sichuan Rhesus Macaques

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The rhesus macaque (Macaca mulatta) is perhaps the most widely distributed nonhuman primate, is used more extensively than any other primate species as animal models for the study of biomedicine. In this study, we sequenced and analysed a fragment of 491 bp of mitochondrial DNA (mtDNA) partial control region in 230 individuals belonging to 8 populations of Sichuan province of China. Among the 230 individuals, we observed 56 different haplotypes defined by 110 polymorphic sites. The average number of nucleotide differences (k) was 18.844, indicating that very high genetic differentiation and the extant Sichuan wild rhesus macaques population consists of diverse genetic groups in their maternal lineage. The mtDNA haplotypes of these Sichuan wild rhesus macaques clustered into two main clades (CladeⅠand Clade Ⅱ), may correspond to M. m. vestitus and M.m.lasiotis.

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Periodical:

Advanced Materials Research (Volumes 343-344)

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683-689

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September 2011

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[1] J . Satkoski, R. Malhi, S. Kanthaswamy, et al. Pyrosequencing as a method for SNP identification in the rhesus macaque (Macaca mulatta),. BMC genomics, 9(1): 256, (2008).

DOI: 10.1186/1471-2164-9-256

Google Scholar

[2] S. O'Connor, A. Blasky, C. Pendley, et al. Comprehensive characterization of MHC class II haplotypes in Mauritian cynomolgus macaques,. Immunogenetics, 59(6): 449-462, (2007).

DOI: 10.1007/s00251-007-0209-7

Google Scholar

[3] D.G. Smith and J . McDonough. Mitochondrial DNA variation in Chinese and Indian rhesus macaques (Macaca mulatta),. Am J Primatol, 65(1): 1-25, (2005).

DOI: 10.1002/ajp.20094

Google Scholar

[4] D.G. Smith. Genetic heterogeneity in five captive specific pathogen-free groups of rhesus macaques,. Laboratory animal science, 44(3): 200, (1994).

Google Scholar

[5] D.G. Smith, S. Kanthaswamy, J. Viray, et al. Additional highly polymorphic microsatellite(STR) loci for estimating kinship in rhesus macaques(Macaca mulatta),. American Journal of Primatology, 50(1): 1-7, (2000).

DOI: 10.1002/(sici)1098-2345(200001)50:1<1::aid-ajp1>3.0.co;2-t

Google Scholar

[6] J.A. Karl, R.W. Wiseman, K.J. Campbell, et al. Identification of MHC class I sequences in Chinese-origin rhesus macaques,. Immunogenetics, 60(1): 37-46, (2008).

DOI: 10.1007/s00251-007-0267-x

Google Scholar

[7] X. Ma, L.H. Tang, L.B. Qu, et al. Identification of 17 novel major histocompatibility complex-A alleles in a population of Chinese-origin rhesus macaques,. Tissue Antigens, 73(2): 184-187, (2009).

DOI: 10.1111/j.1399-0039.2008.01168.x

Google Scholar

[8] H.L. Xu, D. Y. Li, A. C. Cheng, Y. F. Yao, Q. Y. Ni, W. Zeng, F. J. Bi, Z. X. Yang, X. Y. Chen. Population genetic diversity and structure of Rhesus macaque ( Macaca mulatta ) in Sichuan Province based on mtDNA control region sequences,. Acta Theriologica Sinica, 30 (3): 247 – 255, (2010).

Google Scholar

[9] R. Malhi, B. Sickler, D. Lin, et al. MamuSNP: a resource for Rhesus Macaque (Macaca mulatta) genomics,. PLoS ONE, 2(5), (2007).

DOI: 10.1371/journal.pone.0000438

Google Scholar

[10] L. R. Cann, M. Stoneking and C. A. Willson. Mitochondrial DNA and human evolution,. Nature, 325(1): 31-36, (1987).

DOI: 10.1038/325031a0

Google Scholar

[11] D.J. Melnick and G.A. Hoelzer. What is mtDNA good for in the study of primate evolution? , Evolutionary Anthropology: Issues, News, and Reviews, 2(1): 2-10, (1993).

DOI: 10.1002/evan.1360020103

Google Scholar

[12] J. Avise, J. Arnold, R. Ball, et al. Intraspecific phylogeography: the mitochondrial DNA bridge between population genetics and systematics,. Annual Review of Ecology and Systematics, 18(1): 489-522, (1987).

DOI: 10.1146/annurev.es.18.110187.002421

Google Scholar

[13] T. Parsons, D. Muniec, K. Sullivan, et al. A high observed substitution rate in the human mitochondrial DNA control region,. Nature Genetics, 15(4): 363-368, (1997).

DOI: 10.1038/ng0497-363

Google Scholar

[14] J. Sambrook, E.F. Fritsch and T. Maniatis. Molecular cloning, a laboratory manual,. New York: Cold Spring Harbor Laboratory Press, (1989).

DOI: 10.1002/jobm.19840240107

Google Scholar

[15] N.G. Gokey, Z. Cao, J.W. Pak, et al. "Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys. Aging Cell, 3(5): 319-326, (2004).

DOI: 10.1111/j.1474-9728.2004.00122.x

Google Scholar

[16] P. Librado and J. Rozas. DnaSP v5: a software for comprehensive analysis of DNA polymorphism data,. Bioinformatics, 25(11): 1451-1452, (2009).

DOI: 10.1093/bioinformatics/btp187

Google Scholar

[17] K. Tamura, J. Dudley, M. Nei, et al. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4. 0., Mol Biol Evol, 24(8): 1596-1599, (2007).

DOI: 10.1093/molbev/msm092

Google Scholar

[18] H. Bandelt, P. Forster and A. Rohl. Median-joining networks for inferring intraspecific phylogenies,. Molecular Biology and Evolution, 16(1): 37, (1999).

DOI: 10.1093/oxfordjournals.molbev.a026036

Google Scholar

[19] L. Excoffier, P.E. Smouse and J.M. Quattro. Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data,. Genetics, 131(2): 479-491, (1992).

DOI: 10.1093/genetics/131.2.479

Google Scholar

[20] S. Schneider, J. Kueffer, D. Roessli, et al. Arlequin ver. 1. 1: a software for population genetic data analysis,. Genetics and Biometry Laboratory, University of Geneva, Switzerland, (1997).

Google Scholar

[21] M. Nei. Molecular evolutionary genetics [M],. New York: Columbia Univ. Press, (1987).

Google Scholar

[22] C. Millar and W. Libby. Strategies for conserving clinal, Ccotypic, Ana disjunct population diversity in widespread species [A],. In: D.A. Fald, K.E. Holsinger, Genetics and Conservation of Rare Plants [M]. New York: Oxford University Press, 149-170, (1991).

Google Scholar

[23] B. Su, Y. Fu, Y. Wang, et al. Genetic diversity and population history of the red panda (Ailurus fulgens) as inferred from mitochondrial DNA sequence variations,. Molecular Biology and Evolution, 18(6): 1070, (2001).

DOI: 10.1093/oxfordjournals.molbev.a003878

Google Scholar

[24] X.L. Jiang, Y.X. Wang and S.L. Ma. Taxonomic revision and distribution of subspecies of rhesus monkey (Macaca mulatta) in China., Zoological research, 12(3): 241-247, (1991).

Google Scholar