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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 528In Vivo and In Vitro Studies of Biodegradable WE43...

In Vivo and In Vitro Studies of Biodegradable WE43 Stent

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Abstract:

Magnesium alloys are very biocompatible and show promise for use in implant device. The focus of this article lies in the evaluation of the degradation performance and biological response of a paclitaxel-eluting biodegradable stent based on WE43 magnesium alloy by in vivo and in vitro studies. The corrosion characteristics analyzed by immersion testing in phosphate buffered solution (PBS) for 24h. Severe corrosion took place reveal fast degradation, lead to the stent strut easily fracture during expanding. The chemical nature of this conversion in vivo was investigated by scanning electron microscope (SEM) equipped with energy dispersive spectrum (EDS). For the endothelial surface coverage and the microstructure of the stent were also investigated by SEM. The results show that the deployment of the stent in arteries was safe, endothelial coverage occurred above stent struts and between struts after implanted 6 weeks, and more slowly than stainless steel stent and paclitaxel-eluting stainless steel stent. The grains boundaries of the stents are easily corroded in vivo environment, which should strongly affect the radial strength and mechanical integrity of the stent, leading early recoil contribute to restenosis.

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Materials and Mechanical Engineering

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Periodical:

Applied Mechanics and Materials (Volume 528)

Pages:

70-76

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.528.70

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Online since:

February 2014

Authors:

Chun Lan Lu*, He Yan Dong, Wei Wang, Gang Yang

Keywords:

Biodegradation, Endotheliazation, Magnesium Alloy, Vascular Stent

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* - Corresponding Author

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