The Blood Lead Level and Fresh Blood Quick Native Immune Reaction

Shi Guang Li; Kui Fu; Qing Hao Kong; Xian Guo Wu

doi:10.4028/www.scientific.net/AMM.140.235

Paper Titles

Radiological Abnormalities and Clinical Characteristics for Children with Kashin-Beck Disease in Tibet
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Screening Method for Real-Time Detection of Influenza-A Virus in Human Throat Swabs by Surface Plasmon Resonance Biosensor
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Special Technical Problems in Rotary Heart Pumps
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Study on the Property Change of Processed Rhizoma Coptidis Based on 5-HT Level and Brain Tissues Morphology of Rats
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The Blood Lead Level and Fresh Blood Quick Native Immune Reaction
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Therapeutic Efficacy of Hyperbaric Oxygen on the Severe Acute Mountain Sickness Complicated with MODS
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Treatment of Ventricular Tachycardia Storm
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Trigeminocerebellar Projection in the Carp (Cyprinus carpio)
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Analysis of Volatile Compounds of Mycelia of Hirsutella sinensis, the Anamorph of Ophiocordyceps sinensis
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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 140The Blood Lead Level and Fresh Blood Quick Native...

The Blood Lead Level and Fresh Blood Quick Native Immune Reaction

Abstract:

Although we have gained much information about lead-induced organ damage, the effect of blood lead level on fresh blood quick native immune reaction on cancer cells is yet to be determined. The aim of study is evaluating the significance of blood level, as an indicator for environmental lead, and fresh blood quick native immune reaction on cancer cells as an effect indicator, to determinate the correlation between the content of blood lead and quick native immune reaction on cancer. The 120 children from area to exposure environmental lead were recruited into the study using cancer cells adding in fresh anti-coagulate blood to incubation at 37°C for 30 minutes and study of blood lead level using graphite stove atom absorption spectrophotometer, with blood lead level of 0.48μmol/L as a cut off value. blood lead level and fresh blood quick native immune reaction on cancer cells expression were measured with graphite furnace atomic absorption spectroscopy and using cancer cells adding in fresh anti-coagulate blood to incubation at 37°C for 30 minutes respectively. Student t test was used in data analysis, and correlation analysis was used to assess the correlation between blood lead level and expression of cancer cells adding in fresh anti-coagulate. Date from all 120 children was used for data analysis. Expression of TRR and TLR were lower in Group 1(lead level ≥0.48μmol/L) than Group 3(lead level 0.24μmol/L)(t=3.48, 2.32,P<0.01). When the blood lead level was ≥0.48μmol/L, the blood lead level showed significant inverse correlation with TRR and TLR(r=-0.703,-0.606 P<0.01). The result revealed the level of fresh blood quick native immune reaction on cancer cells was a significant difference between groups of high and low blood lead levels. There was correlation in the level of blood lead and fresh blood quick native immune reaction on cancer cells. The result suggested that the high blood lead level may be regarded as an adverse effect on children’s immune function especially on TRR.TLR percentage when exposed environmental lead.

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Periodical:

Applied Mechanics and Materials (Volume 140)

Pages:

235-237

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.140.235

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Online since:

November 2011

Authors:

Shi Guang Li, Kui Fu, Qing Hao Kong, Xian Guo Wu

Keywords:

Cancer Cell, Lead Exposure, Native Immune Reaction

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