Welcome to the InfoSci Platform
Single Nucleotide Polymorphism and its Application in Mapping Loci Involved in Developing Human Diseases and Traits

Single Nucleotide Polymorphism and its Application in Mapping Loci Involved in Developing Human Diseases and Traits

Rui-Ru Ji
Copyright: © 2012 |Volume: 3 |Issue: 4 |Pages: 15
ISSN: 1947-3133|EISSN: 1947-3141|EISBN13: 9781466611245|DOI: 10.4018/ijcmam.2012100106
Cite Article Cite Article

MLA

Ji, Rui-Ru. "Single Nucleotide Polymorphism and its Application in Mapping Loci Involved in Developing Human Diseases and Traits." IJCMAM vol.3, no.4 2012: pp.61-75. http://doi.org/10.4018/ijcmam.2012100106

APA

Ji, R. (2012). Single Nucleotide Polymorphism and its Application in Mapping Loci Involved in Developing Human Diseases and Traits. International Journal of Computational Models and Algorithms in Medicine (IJCMAM), 3(4), 61-75. http://doi.org/10.4018/ijcmam.2012100106

Chicago

Ji, Rui-Ru. "Single Nucleotide Polymorphism and its Application in Mapping Loci Involved in Developing Human Diseases and Traits," International Journal of Computational Models and Algorithms in Medicine (IJCMAM) 3, no.4: 61-75. http://doi.org/10.4018/ijcmam.2012100106

Export Reference

Mendeley
Favorite Full-Issue Download

Abstract

Common diseases or traits in humans are often influenced by complex interactions among multiple genes as well as environmental and lifestyle factors rather than being attributable to a genetic variation within a single gene. Identification of genes that confer disease susceptibility can be facilitated by studying DNA markers such as single nucleotide polymorphism (SNP) associated with a disease trait. Genome-wide association approaches offers a systematic analysis of the association of hundreds of thousands of SNPs with a quantitative complex trait. This method has been successfully applied to a wide variety of common human diseases and traits, and has generated valuable findings that have improved the understanding of the genetic basis of many complex traits. This article outlines the general mapping process and methods, highlights the success stories, and describes some limitations and challenges that lie ahead.

Request Access

You do not own this content. Please login to recommend this title to your institution's librarian or purchase it from the IGI Global bookstore.